Evidence map›Paper›PMID 31754396›Full record

ArticleTheranostics2019

Conditional knockout of TGF-βRII /Smad2 signals protects against acute renal injury by alleviating cell necroptosis, apoptosis and inflammation.

Qin Yang, Gui-Ling Ren, Biao Wei, Juan Jin, Xiao Ru Huang, Wei Shao, Jun Li, Xiao-Ming Meng, Hui Yao Lan

Open access · goldAbstract read
In one paragraph

Article in Theranostics, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed, 1 pooled it
5.7field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed, 1 synthesis or guideline pooled it, 117 citations in OpenAlex.

  1. The Effects of Cannabinoids on Ischemic Stroke-Associated Neuroinflammation: A Systematic Review.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025
    Pooled it
  2. Review
  3. Review
  4. Review
  5. Review
  6. Review
  7. PARylation promotes acute kidney injuryActa pharmaceutica Sinica. B · 2025
    Article
  8. Advances in Nano-Immunomodulatory Systems for the Treatment of Acute Kidney Injury.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Review
  9. Article
  10. Article
  11. Review
  12. Article
  13. Targeting necroptosis in fibrosis.Molecular biology reports · 2023
    Review
  14. The AKI-to-CKD Transition: The Role of Uremic Toxins.International journal of molecular sciences · 2023
    Review
  15. Article
  16. Article
  17. Article
  18. STING deficiency protects against wasp venom-induced acute kidney injury.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2023
    Article
  19. Review
  20. Overexpressed miR-539 exacerbatesPrecision clinical medicine · 2023
    Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Qin YangThe Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University; The key laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei 230032, China.
Gui-Ling RenThe Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University; The key laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei 230032, China.
Biao WeiThe Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University; The key laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei 230032, China.
Juan JinSchool of Basic Medical Sciences, Anhui Medical University. Anhui, China.
Xiao Ru HuangDepartment of Medicine & Therapeutics, Li Ka Shing Institute of Health Sciences, and Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.
Wei ShaoSchool of Basic Medical Sciences, Anhui Medical University. Anhui, China.
Jun LiThe Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University; The key laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei 230032, China.
Xiao-Ming MengThe Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University; The key laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei 230032, China.
Hui Yao LanDepartment of Medicine & Therapeutics, Li Ka Shing Institute of Health Sciences, and Shenzhen Research Institute, The Chinese University of Hong Kong, Hong Kong, China.
Chinese University of Hong Kong · CNChinese People's Liberation Army · CNChinese University of Hong Kong, Shenzhen · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Acute Kidney InjuryAnimalsApoptosisCell LineFlow CytometryHumansImmunohistochemistryImmunoprecipitationInflammationIn Situ Nick-End LabelingKidneyMaleMiceMice, Inbred C57BLMice, KnockoutMicroscopy, FluorescenceReceptor, Transforming Growth Factor-beta Type ISmad2 ProteinAcute kidney injuryApoptosisCisplatinInflammationNecroptosisSmad2TGF-β receptor

Identifiers

PMID31754396
PMCPMC6857044
OpenAlexW2982433954

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.