ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie2020
Ocular vascular changes during pregnancy: an optical coherence tomography angiography study.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.
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Who cites it
15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 29 citations in OpenAlex.
- Retinal and choroidal microvascular features during pregnancy: a systematic review and meta-analysis.BMJ open · 2024Pooled it
- Corneal Biomechanical Changes in Third Trimester of Pregnancy.Medicina (Kaunas, Lithuania) · 2021Pooled it
- OCTA-based assessment of macular and peripapillary vessel changes during the menstrual cycle.BMC ophthalmology · 2025Article
- Evaluating the Chorioretinal Microcirculation in Preeclampsia with OCT-Angiography: A Narrative Literature Review.Journal of clinical medicine · 2025Review
- Changes in Optical Coherence Tomography Angiography Precede Clinical Onset of Placental Insufficiency.Investigative ophthalmology & visual science · 2025Article
- Changes in retinal capillary density in female with type 2 diabetes and gestational diabetes-an analysis based on OCTA technology.International journal of ophthalmology · 2025Article
- Optical coherence tomography angiography evaluation of retinal and choroidal microvascular changes in pregnant women with a history of unexplained recurrent spontaneous abortions.Archives of gynecology and obstetrics · 2024Article
- Chorioretinal biomarkers in hypothalamic amenorrhea.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2024Observational
- Axial length, more than aging, decreases the thickness and superficial vessel density of retinal nerve fiber layer in non-glaucomatous eyes.International ophthalmology · 2024Article
- Assessment of Maternal Retinal Microvasculature in Preterm Pregnancy Using OCT-Angiography: a Cross-Sectional Study.Maedica · 2023Article
- Diabetic retinopathy in pregnancy - A review.Indian journal of ophthalmology · 2021Review
- Retinal vessel diameters, flicker-induced retinal vasodilation and retinal oxygen saturation in high- and low-risk pregnancy.Acta ophthalmologica · 2021Article
- Macular vascular changes in pregnant women with gestational diabetes mellitus by optical coherence tomography angiography.BMC ophthalmology · 2021Article
- Normative Data of Superficial Retinal Vascular Plexus and the Relationship to Retinal Layers.Beyoglu eye journal · 2021Article
- Retinal Vascular Changes during the Menstrual Cycle Detected with Optical Coherence Tomography Angiography.Journal of ophthalmology · 2021Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPregnancy is a period presenting with many physiological adaptation mechanisms. One of the structures in which these mechanisms are observed is ocular tissues. The cornea, lacrimal and meibomian glands, and chorioretinal complex are all among the structures affected by changes during pregnancy. In this study we aimed to evaluate the macular and optic disc vessel density (VD) changes by Optical Coherence Tomography Angiography (OCTA) imaging in pregnancy.
methodsA total of 248 eyes from 124 pregnant women and 80 eyes from 40 healthy control women were involved. Vessel densities of macula were evaluated for superficial capillary plexus (SCP) and deep capillary plexus (DCP) in whole macula, foveal, parafoveal and perifoveal region. Peripapillary and whole optic disc VDs were also evaluated. Vessel densities of macula and optic disc were compared between control individuals and pregnant women. Vessel densities in different trimesters were also evaluated.
resultsModest but significant differences in VDs of whole macula of SCP and DCP were observed in pregnancy group. Additionally, perifoveal and parafoveal region of SCP, whole disc and radial peripapillary capillary VD were significantly higher in pregnancy group. There was no correlation between VD ratios of macula and optic disc and pregnancy weeks and trimesters.
conclusionsThis is the first study focusing on the OCTA parameters in pregnant individuals. These findings suggest that physiological changes during pregnancy are not limited to the cornea, eyelids and the choroid but also to the retinal and optic disc vasculature.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.