Evidence map›Paper›PMID 31760155›Full record

ReviewCurrent opinion in cell biology2020

Patterning and polarization of cells by intracellular flows.

Rukshala Illukkumbura, Tom Bland, Nathan W Goehring

Abstract readReview
In one paragraph

Review in Current opinion in cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

28 citing papers in PubMed.

  1. Article
  2. Article
  3. Subcellular systems follow Onsager reciprocity.npj biomedical innovations · 2025
    Article
  4. Review
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  14. Review
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  18. Article
  19. Article
  20. Self-organization in amoeboid motility.Frontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Rukshala IllukkumburaThe Francis Crick Institute, London, UK.
Tom BlandThe Francis Crick Institute, London, UK; Institute for the Physics of Living Systems, University College London, London, UK.
Nathan W GoehringThe Francis Crick Institute, London, UK; Institute for the Physics of Living Systems, University College London, London, UK; MRC Laboratory for Molecular Cell Biology, University College London, London, UK. Electronic address: nate.goehring@crick.ac.uk.

Funding

Cancer Research UK FC001086Medical Research Council FC001086Wellcome Trust FC001086
6 · The paper itself

Abstract

Beginning with Turing's seminal work [1], decades of research have demonstrated the fundamental ability of biochemical networks to generate and sustain the formation of patterns. However, it is increasingly appreciated that biochemical networks also both shape and are shaped by physical and mechanical processes [2, 3, 4]. One such process is fluid flow. In many respects, the cytoplasm, membrane and actin cortex all function as fluids, and as they flow, they drive bulk transport of molecules throughout the cell. By coupling biochemical activity to long-range molecular transport, flows can shape the distributions of molecules in space. Here, we review the various types of flows that exist in cells, with the aim of highlighting recent advances in our understanding of how flows are generated and how they contribute to intracellular patterning processes, such as the establishment of cell polarity.

Indexed as

ActomyosinAnimalsCell PolarityCytoplasmDrosophilidaeActomyosinActomyosinAdvectionCell polarityCortical flowMembrane flowSelf-organization

Identifiers

PMID31760155
PMCPMC6968950

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.