ArticleSaudi journal of biological sciences2019
Genetic variants of glutathione S-transferase and the risk of acute myeloid leukemia in a Saudi population.
Article in Saudi journal of biological sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.
- Association Between the Individual and Combined Effects of theFrontiers in genetics · 2022Pooled it
- Genetic Insights Into Leukemia Susceptibility in the Arab Population: A Scoping Review.Cureus · 2024Article
- Association of genetic predisposition studies inSaudi journal of biological sciences · 2024Article
- Increased Oxidative Stress in Acute Myeloid Leukemia Patients after Red Blood Cell Transfusion, but Not Platelet Transfusion, Results Mainly from the Oxidative/Nitrative Protein Damage: An Exploratory Study.Journal of clinical medicine · 2021Article
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1 author at 1 institution in 1 country.
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Abstract
objectiveThis study aims to investigate the genetic association of acute myeloid leukemia and glutathione S-transferase (GST) gene polymorphisms in a Saudi population.
method100 AML cases and 100 healthy controls were recruited from the Riyadh regional hospital. In the GST gene, GSTM1 and GSTT1 variants were genotyped by multiplex PCR, and GSTP1 variants were genotyped by PCR-RFLP analysis. Statistical analysis between AML cases and controls included anthropometric measurements and evaluation of the genotypic and allelic frequencies.
resultThe null genotypes of GSTM1 and GSTT1 showed no association with AML [OR 0.56 (0.26-1.19); p = 0.31 and OR 0.65 (0.37-1.16); p = 0.14]. Similarly, the GSTP1 genotype and allele frequencies did not indicate any association with AML [GG + AG vs. AA: OR 0.75 (0.43-1.31) and p = 0.32; GG vs. AA: OR 1.73 (0.55-5.44) and p = 0.34; G vs. A: OR 0.95 (0.61-1.46) and p = 0.82]. Further, a haplotype analysis between AML cases and controls did not show any positive association (p < 0.05).
conclusionIn conclusion, there was no statistical association of the genotypes and alleles in GSTM1, GSTT1, and GSTP1 with AML. Our results confirm the negative association of the investigated genetic markers with susceptibility to AML. Further association studies would be required in different ethnic populations to facilitate a
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