ArticleNutrition and healthy aging2019
Central nervous system SIRT1 expression is required for cued and contextual fear conditioning memory responses in aging mice.
Article in Nutrition and healthy aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Alterations of mitochondrial dynamics in serotonin transporter knockout rats: A possible role in the fear extinction recall mechanisms.Frontiers in behavioral neuroscience · 2022Article
- Astaxanthin alleviates pathological brain aging through the upregulation of hippocampal synaptic proteins.Neural regeneration research · 2021Article
- Exogenous NADAntioxidants (Basel, Switzerland) · 2021Article
- The effects of lithium chloride and cathodal/anodal transcranial direct current stimulation on conditional fear memory changes and the level of p-mTOR/mTOR in PFC of male NMRI mice.Metabolic brain disease · 2021Article
- MicroRNA-138 Overexpression Alters Aβ42 Levels and Behavior in Wildtype Mice.Frontiers in neuroscience · 2020Article
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSirtuin 1 (SIRT1) is a NAD
objectiveTo investigate the role of brain-associated SIRT1 expression in the acquisition of fear memory in mice at 45 and 65 weeks of age.
methodsMice with brain-specific knock-out or overexpression of
resultsIn the current study, mice lacking the expression of brain SIRT1 could not learn the fear conditioning paradigm during training, context, or cue phases.
conclusionsThe results of the study indicate that SIRT1 expression in the brain is critical for the formation of fear memory in male mice at two distinct ages, highlighting the essential role of SIRT1 in fear memory acquisition during aging.
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