ReviewNature reviews. Molecular cell biology2020
Molecular mechanisms and physiological importance of circadian rhythms.
Review in Nature reviews. Molecular cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 766 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Impact of Circadian Rhythm-Based Medication Timing Adjustment on the Efficacy and Safety of Novel Hormonal Therapy
Longitudinal Patterns of Use of the Circadian OS iPad-Based Light App, With Optional Biomarker Collection
Who cites it
766 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Associations between prevalent unhealthy lifestyles and the gut microbiota: a comprehensive multi-database bibliometric analysis of pathogenic mechanisms and clinical trajectories.Frontiers in medicine · 2026Pooled it
- Gut microbiota-regulated glutathione metabolic rhythms restore obesity-induced colonic inflammatory oscillations.Gut microbes · 2026Article
- Circadian synchronization between diet and gut microbiota in modulating host's health.Gut microbes · 2026Review
- The retinoic acid-related orphan receptors (RORs) signaling axis in skeletal homeostasis: mechanistic insights and chronotherapeutic prospects.Annals of medicine · 2026Review
- Circadian reprogramming of inflammation and metabolism in chronic kidney disease.Renal failure · 2026Article
- Circadian regulation of hepatic detoxification: implications for drug-induced liver injury.Archives of toxicology · 2026Review
- The transcriptional cortical response to daily torpor inLife science alliance · 2026Article
- Natural Variation in Drosophila melanogaster Clock PolyQ Length: Geographic Gradients and Functional Properties.Molecular ecology · 2026Article
- Rev-erb-α in Skeletal Muscle Adaptation: Integrating Circadian Control Mechanisms and Exercise Dynamic Responses.Journal of cellular physiology · 2026Review
- The Circadian Skin: Chronobiology as a New Frontier in Dermatological Therapy.Dermatology and therapy · 2026Review
- Precision Prevention for Health: The Global Alliance Framework for the Promotion of Physical Activity.Sports medicine (Auckland, N.Z.) · 2026Article
- REV-ERB-Mediated Regulation of Neural Functional Mechanisms by Phytochemicals in the Circadian System.Nutrients · 2026Review
- Review
- Emerging genetics of sleep and circadian disorders.Current opinion in pediatrics · 2026Article
- Dynamic Atlas and Energy Metabolism Adaptation of the Liver Proteome During a 24 h Cycle inBiomolecules · 2026Article
- E4BP4 interacts with PERK to form a feedback loop mediating cold-induced female reproductive disorders.Cell stress & chaperones · 2026Article
- Advances in monitoring mammalian circadian components and their rhythms using reporter systems.RSC chemical biology · 2026Review
- Molecular mechanisms and pathogenesis of MASH.Nature · 2026Review
- Differential effects of sex and age on daily and infradian rhythms of mice.The Journal of physiology · 2026Article
- Intracrine androgen metabolism in the meibomian gland: regulation, circadian control, and implications in dry eye disease.Endocrine journal · 2026Review
706 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To accommodate daily recurring environmental changes, animals show cyclic variations in behaviour and physiology, which include prominent behavioural states such as sleep-wake cycles but also a host of less conspicuous oscillations in neurological, metabolic, endocrine, cardiovascular and immune functions. Circadian rhythmicity is created endogenously by genetically encoded molecular clocks, whose components cooperate to generate cyclic changes in their own abundance and activity, with a periodicity of about a day. Throughout the body, such molecular clocks convey temporal control to the function of organs and tissues by regulating pertinent downstream programmes. Synchrony between the different circadian oscillators and resonance with the solar day is largely enabled by a neural pacemaker, which is directly responsive to certain environmental cues and able to transmit internal time-of-day representations to the entire body. In this Review, we discuss aspects of the circadian clock in Drosophila melanogaster and mammals, including the components of these molecular oscillators, the function and mechanisms of action of central and peripheral clocks, their synchronization and their relevance to human health.
Indexed as
Identifiers
31768006What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.