Evidence map›Paper›PMID 31768486›Full record

ReviewAPL bioengineering2019

Microphysiological systems modeling acute respiratory distress syndrome that capture mechanical force-induced injury-inflammation-repair.

Hannah Viola, Jonathan Chang, Jocelyn R Grunwell, Louise Hecker, Rabindra Tirouvanziam, James B Grotberg, Shuichi Takayama

Abstract readReview
In one paragraph

Review in APL bioengineering, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Clinical Translation of Engineered Pulmonary Vascular Models.Advances in experimental medicine and biology · 2023
    Article
  7. Review
  8. Multiscale modeling in disease.Current opinion in systems biology · 2021
    Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Advancing humanExpert opinion on drug delivery · 2020
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jonathan ChangWallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology and Emory School of Medicine, Atlanta, Georgia 30332, USA.
Jocelyn R GrunwellDepartment of Pediatrics, Division of Critical Care Medicine, Children's Healthcare of Atlanta at Egleston, Emory University School of Medicine, Atlanta, Georgia 30322, USA.
Louise HeckerDivision of Pulmonary, Allergy and Critical Care and Sleep Medicine, University of Arizona, Tucson, Arizona 85724, USA and Southern Arizona Veterans Affairs Health Care System, Tucson, Arizona 85723, USA.
Rabindra TirouvanziamDepartment of Pediatrics, Emory University School of Medicine, Atlanta, Georgia 30322, USA and Center for CF and Airways Disease Research, Children's Healthcare of Atlanta, Atlanta, Georgia 30322, USA.
James B GrotbergDepartment of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan 48109, USA.
Shuichi Takayama

Funding

Atlanta Pediatric Scholars ProgramK12HD072245 · NICHD · EMORY UNIVERSITY · PI Shari Barkin · 2012 to 2026
$5.5M
Microfluidic Tissue Engineering of Small Airway InjuriesR01HL136141 · NHLBI · GEORGIA INSTITUTE OF TECHNOLOGY · PI GROTBERG, JAMES BERNARD, NEMZEK, JEAN A · 2017 to 2020
$2.9M
Graduate Training for Rationally Designed, Integrative Biomaterials - GT BioMATT32EB006343 · NIBIB · GEORGIA INSTITUTE OF TECHNOLOGY · PI TEMENOFF, JOHNNA S · 2008 to 2018
$2.2M
Contribution of neutrophils to early airway disease in cystic fibrosis childrenR01HL126603 · NHLBI · EMORY UNIVERSITY · PI TIROUVANZIAM, RABINDRA MARIE-JEAN · 2015 to 2018
$1.7M
3D High Throughput Model to Predict Drug Efficacy in Fibrosis Progression vs ReversalR21AG061687 · NIA · GEORGIA INSTITUTE OF TECHNOLOGY · PI HECKER, LOUISE, TAKAYAMA, SHUICHI · 2019 to 2020
$445k
Preclinical development of a novel Nrf2-activator formulation for the treatment of idiopathic pulmonary fibrosisR21AG054766 · NIA · UNIVERSITY OF ARIZONA · PI HECKER, LOUISE, MANSOUR, HEIDI M. · 2017 to 2018
$415k
Novel Targeting of the S1P Receptor, S1P1, and Nox4 as Therapeutic Approaches in ARDSR41HL140741 · NHLBI · RESTORE THERAPEUTICS, LLC · PI GARCIA, JOE G. N. · 2018 to 2018
$225k
The role of Nampt in age-associated persistent lung fibrosisI01BX003919 · VA · VETERANS HEALTH ADMINISTRATION · PI HECKER, LOUISE · 2018 to 2022
–
BLRD VA I01 BX003919NHLBI NIH HHS R01 HL126603NHLBI NIH HHS R01 HL136141NHLBI NIH HHS R41 HL140741NIA NIH HHS R21 AG054766NIA NIH HHS R21 AG061687NIBIB NIH HHS T32 EB006343NICHD NIH HHS K12 HD072245
6 · The paper itself

Abstract

Complex

Identifiers

PMID31768486
PMCPMC6874511

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.