Evidence map›Paper›PMID 31769248›Full record

ArticleYonsei medical journal2019

Serum Procollagen Type I N-Terminal Propeptide and Osteocalcin Levels in Korean Children and Adolescents.

Ji Seon Choi, Ikchun Park, Soo Jung Lee, Hyo Jin Ju, Hyeyoung Lee, Jayoung Kim

Open access · goldAbstract read
In one paragraph

Article in Yonsei medical journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 29 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Variation of Bone Turnover Markers in Childhood and Adolescence.International journal of clinical practice · 2023
    Article
  6. Broad application prospects of bone turnover markers in pediatrics.Journal of clinical laboratory analysis · 2022
    Review
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Ji Seon ChoiDepartment of Laboratory Medicine, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, Korea.ORCID https://orcid.org/0000-0002-9179-4517
Ikchun ParkDepartment of Laboratory Medicine, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, Korea.ORCID https://orcid.org/0000-0001-9314-8773
Soo Jung LeeDepartment of Pediatrics, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, Korea.ORCID https://orcid.org/0000-0003-1512-9125
Hyo Jin JuDepartment of Medical Humanities, Catholic Kwandong University College of Medicine, Incheon, Korea.ORCID https://orcid.org/0000-0002-1164-3621
Hyeyoung LeeDepartment of Laboratory Medicine, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, Korea.ORCID https://orcid.org/0000-0001-8871-5091
Jayoung KimDepartment of Laboratory Medicine, International St. Mary's Hospital, Catholic Kwandong University College of Medicine, Incheon, Korea. lmkjy7@gmail.com.ORCID https://orcid.org/0000-0003-2977-1813
Catholic Kwandong University International St. Mary's Hospital · KRIncheon Catholic University · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeBone markers can be useful for the diagnosis and treatment of skeletal diseases in children and adolescents. Owing to high skeletal growth velocity and rapid bone turnover, children and adolescents have higher bone marker levels than adults. Thus, a valid age- and sex-specific reference should be established for pediatric populations living in similar environments. We aimed to assess the associations of procollagen type I N-terminal propeptide (P1NP) and osteocalcin with age and sex in a group of healthy Korean children and adolescents. MATERIALS AND

methodsThe participants (290 boys and 290 girls, age range 0-18 years) were Korean outpatients. Serum P1NP and osteocalcin levels were measured in control materials and patient samples by electrochemiluminescence immunoassay using an automated Cobas e411 analyzer.

resultsSignificant age-dependent variations in bone marker levels were observed in both sexes (

conclusionWe established reference data for P1NP and osteocalcin levels in healthy Korean children and adolescents, as the first and only study of these parameters in pre-adulthood in Korea. Cobas e411-quantified bone markers may be useful for determining bone metabolism indices.

Indexed as

AdolescentAdultBiomarkersBone and BonesBone RemodelingChildChild, PreschoolFemaleHumansInfantInfant, NewbornMaleOsteocalcinPeptide FragmentsProcollagenReference ValuesBiomarkersOsteocalcinPeptide FragmentsProcollagenprocollagen Type I N-terminal peptideadolescentbone markerChildrenosteocalcinP1NP

Identifiers

PMID31769248
PMCPMC6881701
OpenAlexW2990267369

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.