ArticleProceedings of the National Academy of Sciences of the United States of America2019
Universal phase behaviors of intracellular lipid droplets.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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Who cites it
22 citing papers in PubMed, 47 citations in OpenAlex.
- Heterogeneity, dynamics and organelle interactions of lipid droplets.Nature reviews. Molecular cell biology · 2026Review
- Seipin-defined ER sites undergo distinct enrichment of factors for the biogenesis of sterol ester rich lipid droplets.iScience · 2026Article
- Cholesteryl Esters Modulate Lipid Droplet Rigidity and Monolayer Organization during Liver Cancer Progression.bioRxiv : the preprint server for biology · 2026Article
- Kinetically Controlled Self-Assembly of a Lipophilic Fluorophore with Phenylalanine-Based Diamides in Artificial Lipid Droplets.Small (Weinheim an der Bergstrasse, Germany) · 2026Article
- Dynamics of Fanconi anemia protein D2 in association with nuclear lipid droplet formation.Journal of cell science · 2025Article
- Polarization-Sensitive Holotomography for Multidimensional Label-Free Imaging and Characterization of Lipid Droplets in Cancer Cells.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- NCOA7 inhibits renal cancer progression by inducing autophagy and lipid metabolism through V-ATPase interaction.Cell death discovery · 2025Article
- Millisecond Phase Transition Kinetics of Lyotropic Liquid Crystalline Nanoparticles Observed by Time-Resolved Small Angle X-ray Solution Scattering.Chemphyschem : a European journal of chemical physics and physical chemistry · 2025Article
- LRP1 immunotherapy enhances cardiomyocyte respiration by restricting cholesteryl ester accumulation in mitochondria.Journal of lipid research · 2025Article
- Tools to Dissect Lipid Droplet Regulation, Players, and Mechanisms.ACS chemical biology · 2025Review
- Triacylglycerol-droplet-induced bilayer spontaneous curvature in giant unilamellar vesicles.Biophysical journal · 2024Article
- Probing the dynamic landscape of peptides in molecular assemblies by synergized NMR experiments and MD simulations.Communications chemistry · 2024Article
- The (social) lives, deaths, and biophysical phases of lipid droplets.Current opinion in cell biology · 2023Review
- Cholesterol esters form supercooled lipid droplets whose nucleation is facilitated by triacylglycerols.Nature communications · 2023Article
- Seipin-still a mysterious protein?Frontiers in cell and developmental biology · 2023Review
- Lipid droplets go through a (liquid crystalline) phase.The Journal of cell biology · 2022Article
- Triglyceride lipolysis triggers liquid crystalline phases in lipid droplets and alters the LD proteome.The Journal of cell biology · 2022Article
- Diffusion of Squalene in Nonaqueous Solvents.ACS omega · 2022Article
- Computational Studies of Lipid Droplets.The journal of physical chemistry. B · 2022Review
- Depletion of Cholesteryl Esters Causes Meibomian Gland Dysfunction-Like Symptoms in aInternational journal of molecular sciences · 2021Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipid droplets are cytoplasmic microscale organelles involved in energy homeostasis and handling of cellular lipids and proteins. The core structure is mainly composed of two kinds of neutral lipids, triglycerides and cholesteryl esters, which are coated by a phospholipid monolayer and proteins. Despite the liquid crystalline nature of cholesteryl esters, the connection between the lipid composition and physical states is poorly understood. Here, we present a universal intracellular phase diagram of lipid droplets, semiquantitatively consistent with the in vitro phase diagram, and reveal that cholesterol esters cause the liquid-liquid crystal phase transition under near-physiological conditions. We moreover combine in vivo and in vitro studies, together with the theory of confined liquid crystals, to suggest that the radial molecular alignments in the liquid crystallized lipid droplets are caused by an anchoring force at the droplet surface. Our findings on the phase transition of lipid droplets and resulting molecular organization contribute to a better understanding of their biological functions and diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.