Evidence map›Paper›PMID 31773399›Full record

ArticleJournal of molecular neuroscience : MN2020

ANRIL Variants Are Associated with Risk of Neuropsychiatric Conditions.

Amir Namvar, Mir Salar Kahaei, Hamid Fallah, Fwad Nicknafs, Soudeh Ghafouri-Fard, Mohammad Taheri

Abstract read
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In one paragraph

Article in Journal of molecular neuroscience : MN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Circulating long noncoding RNA: New frontiers in biomarker research for mood disorders.Genomic psychiatry : advancing science from genes to society · 2025
    Article
  4. Article
  5. Association betweenHeliyon · 2023
    Article
  6. Article
  7. Epigenetic Modulation of Opioid Receptors by Drugs of Abuse.International journal of molecular sciences · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Amir NamvarDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Mir Salar KahaeiDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Hamid FallahDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Fwad NicknafsDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Soudeh Ghafouri-FardDepartment of Medical Genetics, Shahid Beheshti University of Medical Sciences, Tehran, Iran. s.ghafourifard@sbmu.ac.ir.
Mohammad TaheriUrogenital Stem Cell Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. mohammad_823@yahoo.com.ORCID http://orcid.org/0000-0001-8381-0591

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The antisense non-coding RNA in the INK4 locus (ANRIL) is a long non-coding RNA (lncRNA) whose contribution in several human disorders has been verified. In the current projects, we genotyped two single nucleotide polymorphisms (SNPs) in this lncRNA (rs1333045 and rs1333048) in a population of Iranian patients with bipolar disorder (BP), major depressive disorder (MDD), and methamphetamine addiction. The rs1333045 was associated with methamphetamine addiction in recessive and multiplicative models (OR (95% CI) = 1.867 (1.211-2.877), adjusted p value = 8.75E-03 and OR (95% CI) = 1.415 (1.089-1.839), adjusted p value = 1.87E-02 respectively). The rs1333048 was associated with methamphetamine addiction in co-dominant model (A/A vs. C/C: OR (95% CI) = 0.195 (0.114-0.336), adjusted p value = 2.44E-09) and in other inheritance models. The rs1333045 was not associated with risk of BP I in any inheritance model. However, the rs1333048 was associated with BP I in co-dominant model (A/A vs. C/C: OR (95% CI) = 0.499 (0.286-0.870), adjusted p value = 2.53E-07) and in other inheritance models. In BP II cohort, we detected significant associations between both SNPs and risk of disorder in all inheritance models. In co-dominant model, these associations were detected just between homozygotes (T/T vs. C/C (rs1333045); A/A vs. C/C and (rs1333048)). The rs1333045 was associated with MDD in recessive model (OR (95% CI) = 2.221 (1.173-4.207), adjusted p value = 0.026). The rs1333048 was associated with MDDs in dominant, recessive, and multiplicative models. The selected SNPs were not in linkage disequilibrium (D' statistic = 0.23, r

Indexed as

Polymorphism, Single NucleotideAdultAmphetamine-Related DisordersBipolar DisorderFemaleHumansMajor Depressive DisorderMaleMiddle AgedRNA, Long NoncodingCDKN2B antisense RNA, humanRNA, Long NoncodingANRILAntisense non-coding RNA in the INK4 locusBipolar disorderMajor depressive disorderMethamphetamine addictionrs1333045rs1333048

Identifiers

PMID31773399

What Socratic holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.