ArticleDiagnostics (Basel, Switzerland)2019
Protein Carbonyl Content Is a Predictive Biomarker of Eccentric Left Ventricular Hypertrophy in Hemodialysis Patients.
Article in Diagnostics (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Protein carbonyl: A sensitive marker reflecting oxidative stress in prevalent hemodialysis patients.World journal of nephrology · 2026Article
- Low Plasma Carnosinase-1 Activity in Patients with Left Ventricular Systolic Dysfunction: Implications for Carnosine Therapy in Heart Failure.International journal of molecular sciences · 2025Article
- MBNL2 promotes aging-related cardiac fibrosis via inhibited SUMOylation of Krüppel-like factor4.iScience · 2024Article
- Review
- Relationship between Oxidative Stress and Left Ventricle Markers in Patients with Chronic Heart Failure.Cells · 2023Article
- Plasma advanced oxidation products as an additional tool in assessment of post-infarction heart failure.The Journal of international medical research · 2022Observational
- Glycemic status, non-traditional risk and left ventricular structure and function in the Jackson Heart Study.BMC cardiovascular disorders · 2022Article
- Adeno-associated virus 9 vector-mediated cardiac-selective expression of human secretory leukocyte protease inhibitor attenuates myocardial ischemia/reperfusion injury.Frontiers in cardiovascular medicine · 2022Article
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Authors and funding
4 authors.
Funding
Abstract
High prevalence of left ventricular hypertrophy (LVH) and elevated oxidative stress are associated with poor outcomes in chronic hemodialysis patients. Abnormal left ventriculаr geomеtry and different geometric patterns play an important role as well. Our study analyzed the role of oxidative stress on myocardial remodeling in these patients. Plasma malondialdehyde (MDA), protein carbonyl (PC) content, and total antioxidative capacity (TAC) were investigated in 104 hemodialysis patients together with transthoracic echocardiography. Compared to patients with normal ventricular geometry, patients with LVH had increased MDA and PC plasma concentration. Multivariate analysis demonstrated that protein carbonyls, as biomarkers of oxidative protein modification, were an independent predictor of eccentric hypertrophy (eLVH), including higher LV end-diastolic diameter and LV end-diastolic volume, (β = 0.32 and β = 0.28,
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