ReviewPharmacology, biochemistry, and behavior2020
Therapeutic efficacy of environmental enrichment for substance use disorders.
Review in Pharmacology, biochemistry, and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 54 citations in OpenAlex.
- Impact of environmental enrichment on heroin-induced neuroadaptations in the insula, nucleus accumbens and ventral tegmental area.Neuropharmacology · 2026Article
- Article
- Virtual reality environmental enrichment effects on heart rate variability in healthy volunteers.Psychopharmacology · 2026Article
- To indulge or enrich: how environmental enrichment affects neurons that promote food seeking.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Environmental enrichment attenuates reinstatement of heroin seeking and reverses heroin-induced upregulation of mesolimbic ghrelin receptors.Drug and alcohol dependence · 2025Article
- Sex differences in motivation to take sucrose following abstinence and environmental enrichment in Long-Evans rats.Physiology & behavior · 2025Article
- Environmental Enrichment Has Age- and Sex-Specific Effects on Fear Regulation in Mice.Developmental psychobiology · 2025Article
- Adapting a Functional Assessment of Cigarette Smoking for People with Intellectual and Developmental Disabilities.Behavior analysis in practice · 2025Article
- Physical activity and risk behaviors among adolescents: the mediating roles of diet, sleep, mental health, and substance use.Frontiers in public health · 2025Article
- Moving beyond animal models: enriched environments and human substance use disorders.Frontiers in behavioral neuroscience · 2025Article
- An economon model of drug addiction.Psychopharmacology · 2024Article
- Sex difference in the effect of environmental enrichment on food restriction-induced persistence of cocaine conditioned place preference and mechanistic underpinnings.Addiction neuroscience · 2024Article
- Impact of altered environment and early postnatal methamphetamine exposure on serotonin levels in the rat hippocampus during adolescence.Laboratory animal research · 2024Article
- Environmental Enrichment during Abstinence Reduces Oxycodone Seeking and c-Fos Expression in a Subpopulation of Medial Prefrontal Cortex Neurons.Drug and alcohol dependence · 2024Article
- The effects of virtual reality environmental enrichments on craving to food in healthy volunteers.Psychopharmacology · 2024Article
- The Impact of Heroin Self-Administration and Environmental Enrichment on Ventral Tegmental CRF1 Receptor Expression.The international journal of neuropsychopharmacology · 2023Article
- An Understated Comorbidity: The Impact of Homelessness on Traumatic Brain Injury.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2023Review
- Article
- Environmental enrichment facilitates electric barrier induced heroin abstinence after incubation of craving in male and female rats.Drug and alcohol dependence · 2023Article
- Neurobehavioral effects of environmental enrichment and drug abuse vulnerability: An updated review.Pharmacology, biochemistry, and behavior · 2022Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Addiction to drug and alcohol is regarded as a major health problem worldwide for which available treatments show limited effectiveness. The biggest challenge remains to enhance the capacities of interventions to reduce craving, prevent relapse and promote long-term recovery. New strategies to meet these challenges are being explored. Findings from preclinical work suggest that environmental enrichment (EE) holds therapeutic potential for the treatment of substance use disorders, as demonstrated in a number of animal models of drug abuse. The EE intervention introduced after drug exposure leads to attenuation of compulsive drug taking, attenuation of the rewarding (and reinforcing) effects of drugs, reductions in control of behavior by drug cues, and, very importantly, relapse prevention. Clinical work also suggests that multidimensional EE interventions (involving physical activity, social interaction, vocational training, recreational and community involvement) might produce similar therapeutic effects, if implemented continuously and rigorously. In this review we survey preclinical and clinical studies assessing the efficacy of EE as a behavioral intervention for substance use disorders and address related challenges. We also review work providing empirical evidence for EE-induced neuroplasticity within the mesocorticolimbic system that is believed to contribute to the seemingly therapeutic effects of EE on drug and alcohol-related behaviors.
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.