Evidence map›Paper›PMID 31779593›Full record

ArticleBMC cancer2019

LINC01128 expedites cervical cancer progression by regulating miR-383-5p/SFN axis.

Yi Hu, Yan Ma, Jie Liu, Yanlin Cai, Mengmeng Zhang, Xiaoling Fang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
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  8. Review
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  13. MicroRNA-383: A tumor suppressor miRNA in human cancer.Frontiers in cell and developmental biology · 2022
    Review
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  20. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Yi HuDepartment of Obstetrics and Gynaecology, The Second Xiangya Hospital, Central South University, 139 Renmin road, Changsha, 410011, Hunan, China.
Yan MaDepartment of Obstetrics and Gynaecology, the First Affiliated Hospital of University of South China, Hengyang, 421001, Hunan, China.
Jie LiuDepartment of Obstetrics and Gynaecology, the First Affiliated Hospital of University of South China, Hengyang, 421001, Hunan, China.
Yanlin CaiDepartment of Obstetrics and Gynaecology, the First Affiliated Hospital of University of South China, Hengyang, 421001, Hunan, China.
Mengmeng ZhangDepartment of Obstetrics and Gynaecology, The Second Xiangya Hospital, Central South University, 139 Renmin road, Changsha, 410011, Hunan, China.
Xiaoling FangDepartment of Obstetrics and Gynaecology, The Second Xiangya Hospital, Central South University, 139 Renmin road, Changsha, 410011, Hunan, China. qifangqiang6542@163.com.ORCID http://orcid.org/0000-0002-4597-0030
Central South University · CNFirst Affiliated Hospital of University of South China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCervical cancer (CC), causing significant morbidity and mortality worldwide, is one of the most common gynecological malignancies in women. SFN has been reported as a potential prognostic marker with apparent high expression in tumors. Nevertheless, the function mechanism of SFN is not clear yet in CC.

methodsThe relative expressions of RNAs were detected by real-time quantitative PCR (RT-qPCR). Colony formation assay, EdU stained assay and CCK-8 assay were to check cell proliferation ability in CC. Flow cytometry and apoptosis related proteins analysis were used to measure cells apoptosis capacity. Luciferase reporter assay and RNA pull down assay were to verify the molecular mechanism.

resultsSFN was highly expressed in CC tissues and CC cell lines compared with normal tissues and normal cell line. After interfering SFN, cell proliferation, migration and invasion ability was inhibited as well as cell apoptosis ability was promoted. In subsequence, miR-383-5p exhibited conspicuous low expression in CC tissues. And miR-383-5p was found to bind to SFN and have anti-cancerous effects in CC. Moreover, LINC01128 displayed remarkable high expression in CC tissues. Besides, LINC01128 shortage could reduce the expression of SFN at mRNA and protein levels. And the affinity between LINC01128 and miR-383-5p was verified. In the end, it was proved that LINC01128 could enhance cell proliferation, migration and invasion as well as inhibit cell apoptosis by binding with miR-383-5p and upregulating SFN.

conclusionLINC01128 expedited cells cellular process in CC by binding with miR-383-5p to release SFN.

Indexed as

14-3-3 ProteinsApoptosisBiomarkers, TumorCell Line, TumorCell MovementCell ProliferationDisease ProgressionExoribonucleasesFemaleGene ExpressionGene Expression Regulation, NeoplasticHumansMicroRNAsNeoplasm InvasivenessRNA, Long NoncodingUterine Cervical Neoplasms14-3-3 ProteinsBiomarkers, TumorExoribonucleasesMicroRNAsMIRN383 microRNA, humanRNA, Long NoncodingSFN protein, humanCervical cancerLINC01128miR-383-5pSFN

Identifiers

PMID31779593
PMCPMC6883532
OpenAlexW2989834612

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.