Evidence map›Paper›PMID 31780574›Full record

GuidelineGut2020

Guidelines for the management of hereditary colorectal cancer from the British Society of Gastroenterology (BSG)/Association of Coloproctology of Great Britain and Ireland (ACPGBI)/United Kingdom Cancer Genetics Group (UKCGG).

Kevin J Monahan, Nicola Bradshaw, Sunil Dolwani, Bianca Desouza, Malcolm G Dunlop, James E East, Mohammad Ilyas, Asha Kaur, Fiona Lalloo, Andrew Latchford and 5 more

4 registry-linked trialsAbstract readPractice Guideline
PubMed Full text at PMC Publisher
In one paragraph

Guideline in Gut, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 252 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
252citing papers in PubMed, 13 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04906343 nacompletednot on this mapstarted 2021, after this paper: background citation

Endoscopic Surveillance in Patients With Serrated Polyposis Syndrome and Low-risk of Advanced Neoplasia.

TypeinterventionalSponsorHospital Universitario de MóstolesRan2021 to 2024Enrolled144ConditionsColonic Polyp, Colonic Neoplasms, Colonic Cancer, Serrated PolyposisArmsColonoscopy
NCT06163365 unknown statusnot on this mapstarted 2022, after this paper: background citation

Inherited Cancer Early Diagnosis (ICED) Study Liquid Biopsy Screening for Early Diagnosis of Cancers in Patients With Cancer-predisposition Syndromes

Typeobservational_patient_registrySponsorRoyal Marsden NHS Foundation TrustRan2022 to 2025Enrolled100ConditionsLi Fraumeni Syndrome, Lynch Syndrome, Hereditary Diffuse Gastric Cancer, Cowden Syndrome
NCT06242197 nacompletednot on this mapstarted 2022, after this paper: background citation

Comparing the Effectiveness of Written Advice VS. Standard Verbal Advice in Transferring Knowledge to First Degree Relatives of Colorectal Cancer Patients

TypeinterventionalSponsorRamathibodi HospitalRan2022 to 2024Enrolled180ConditionsColorectal CancerArmswritten advice
NCT06271980 completednot on this mapstarted 2023, after this paper: background citation

Predicting Long-Term Recurrence-Free and Overall Survival in Early-Onset Colorectal Cancer Survivors

TypeobservationalSponsorCity of Hope Medical CenterRan2023 to 2024Enrolled177ConditionsColorectal Cancer Recurrent, Colorectal Cancer, Colorectal Neoplasms, Colorectal AdenocarcinomaArmsENCORE
3 · Its place in the literature

Who cites it

252 citing papers in PubMed, 13 syntheses or guidelines pooled it.

  1. Pooled it
  2. Guideline
  3. Guideline
  4. Pooled it
  5. Pooled it
  6. Guideline
  7. Pooled it
  8. Delphi Initiative for Early-Onset Colorectal Cancer (DIRECt) International Management Guidelines.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2023
    Guideline
  9. Pooled it
  10. Pooled it
  11. Validity of a two-antibody testing algorithm for mismatch repair deficiency testing in cancer; a systematic literature review and meta-analysis.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022
    Pooled it
  12. Pooled it
  13. Pooled it
  14. Trial
  15. Trial
  16. Trial
  17. Trial
  18. Trial
  19. Trial
  20. Outcomes of 'in-house' genetic testing within a specialist hereditary colorectal cancer registry.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2026
    Article

192 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Kevin J MonahanFamily Cancer Clinic, St Mark's Hospital, London, UK k.monahan@imperial.ac.uk.ORCID 0000-0002-7918-4003
Nicola BradshawClinical Genetics, West of Scotland Genetics Services, Glasgow, Glasgow, UK.
Sunil DolwaniGastroenterology, Cardiff and Vale NHS Trust, Cardiff, UK.
Bianca DesouzaClinical Genetics, Guy's and St Thomas' NHS Foundation Trust, London, UK.
Malcolm G DunlopCCGG, University of Edinburgh, Edinburgh, UK.
James E EastTranslational Gastroenterology Unit, John Radcliffe Hospital, Oxford, UK.
Mohammad IlyasFaculty of Medicine & Health Sciences, Nottingham University, Nottingham, UK.
Asha KaurHead of Policy and Campaigns, Bowel Cancer UK, London, UK.
Fiona LallooGenetic Medicine, Central Manchester University Hospitals Foundation Trust, Manchester, UK.
Andrew LatchfordPolyposis Registry, St Mark's Hospital, London, UK.
Matthew D RutterGastroenterology, University Hospital of North Tees, Stockton-on-Tees, UK.ORCID 0000-0001-9507-0295
Ian TomlinsonNuffield Department of Clinical Medicine, Wellcome Trust Centre for Human Genetics, Birmingham, UK.ORCID 0000-0003-3037-1470
Huw J W ThomasFamily Cancer Clinic, St Mark's Hospital, London, UK.
James HillGenetic Medicine, Central Manchester University Hospitals Foundation Trust, Manchester, UK.
Hereditary CRC guidelines eDelphi consensus group

Funding

Cancer Research UK 12076Cancer Research UK 18927Cancer Research UK 27327Department of HealthMedical Research Council MC_PC_U127527198Medical Research Council MC_U127527198Medical Research Council MC_UU_00007/1
6 · The paper itself

Abstract

Heritable factors account for approximately 35% of colorectal cancer (CRC) risk, and almost 30% of the population in the UK have a family history of CRC. The quantification of an individual's lifetime risk of gastrointestinal cancer may incorporate clinical and molecular data, and depends on accurate phenotypic assessment and genetic diagnosis. In turn this may facilitate targeted risk-reducing interventions, including endoscopic surveillance, preventative surgery and chemoprophylaxis, which provide opportunities for cancer prevention. This guideline is an update from the 2010 British Society of Gastroenterology/Association of Coloproctology of Great Britain and Ireland (BSG/ACPGBI) guidelines for colorectal screening and surveillance in moderate and high-risk groups; however, this guideline is concerned specifically with people who have increased lifetime risk of CRC due to hereditary factors, including those with Lynch syndrome, polyposis or a family history of CRC. On this occasion we invited the UK Cancer Genetics Group (UKCGG), a subgroup within the British Society of Genetic Medicine (BSGM), as a partner to BSG and ACPGBI in the multidisciplinary guideline development process. We also invited external review through the Delphi process by members of the public as well as the steering committees of the European Hereditary Tumour Group (EHTG) and the European Society of Gastrointestinal Endoscopy (ESGE). A systematic review of 10 189 publications was undertaken to develop 67 evidence and expert opinion-based recommendations for the management of hereditary CRC risk. Ten research recommendations are also prioritised to inform clinical management of people at hereditary CRC risk.

Indexed as

Population SurveillanceAdenomatous Polyposis ColiColonoscopyColorectal NeoplasmsColorectal Neoplasms, Hereditary NonpolyposisDNA GlycosylasesFamily HealthHumansIntestinal PolyposisIrelandLife StyleNeoplastic Syndromes, HereditaryPeutz-Jeghers SyndromeReferral and ConsultationRisk FactorsUnited KingdomDNA GlycosylasesmutY adenine glycosylasecolorectal cancercolorectal surgerygenetic testinginherited cancerssurveillance

Identifiers

PMID31780574
PMCPMC7034349

What Socratic holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.