ReviewThe British journal of radiology2020
Novel imaging biomarkers: epicardial adipose tissue evaluation.
Review in The British journal of radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07178145 (MRI of Epicardial Adipose Tissue Composition), which is not on this map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
MRI of Epicardial Adipose Tissue Composition: Development of Methods and Application to Heart Failure With Preserved Ejection Fraction
Who cites it
47 citing papers in PubMed, 76 citations in OpenAlex.
- A 12-month structured exercise reduces epicardial adipose volume in a frequency-dependent manner and lowers serum M-CSF in community-dwelling older adults: a randomized controlled trial.Frontiers in public health · 2026Trial
- Epicardial adipose tissue in obesity with heart failure with preserved ejection fraction: Cardiovascular magnetic resonance biomarker study.World journal of cardiology · 2024Trial
- Epicardial and pericardial adipose tissue: anatomy, physiology, imaging, segmentation, and treatment effects.The British journal of radiology · 2026Review
- The Role of Epicardial and Visceral Fat in Severe Respiratory Infections: Associations With Adverse Outcomes.Clinical obesity · 2026Observational
- Modifiable Risk Factors in Atrial Fibrillation: Clinical Implications and Pathophysiological Insights.Annals of noninvasive electrocardiology : the official journal of the International Society for Holter and Noninvasive Electrocardiology, Inc · 2026Review
- A new insight on imaging characteristics of pericoronary adipose tissue for cardiovascular risk.Cardiovascular ultrasound · 2026Review
- Epicardial adipose tissue mediates the association between circulating hsa-miR-4750-3p and coronary artery disease in patients with type 2 diabetes mellitus.Cardiovascular diabetology · 2026Observational
- Macrophage Immunometabolism in Epicardial Adipose Tissue and Obesity-Related Atrial Fibrillation.Journal of inflammation research · 2026Review
- Obesity-Associated Cardiac Fibrosis: Mechanisms and Emerging Therapeutic Targets.Vascular health and risk management · 2026Review
- Regional heterogeneity in left atrial stiffness impacts passive deformation in a cohort of patient-specific models.PLoS computational biology · 2025Article
- A narrative review of epicardial adipose tissue as a predictor of cardiometabolic risk in rheumatoid arthritis patients.Annals of translational medicine · 2025Review
- AI-Driven segmentation and morphogeometric profiling of epicardial adipose tissue in type 2 diabetes.Cardiovascular diabetology · 2025Article
- Association of epicardial fat volume with the severity of coronary artery disease: a preliminary study on risk prediction of obstructive coronary heart disease.BMC cardiovascular disorders · 2025Article
- Detecting severe coronary artery stenosis in T2DM patients with NAFLD using cardiac fat radiomics-based machine learning.Scientific reports · 2025Article
- Evaluating Epicardial Fat Density Using ROI-Based Analysis: A Feasibility Study.Journal of cardiovascular development and disease · 2025Article
- The role of imaging in defining cardiovascular risk to help cancer patient management: a scoping review.Insights into imaging · 2025Review
- Epicardial adipose tissue thickness on transthoracic echocardiography predicts 2-year incident atrial fibrillation in elderly hypertensive patients.Frontiers in cardiovascular medicine · 2025Article
- Association between epicardial and pericadial fat thickness and coronary artery calcification severity in chronic kidney disease patients: A pilot study.ARYA atherosclerosis · 2025Article
- Prognostic Value of Epicardial Fat Volume Quantification Related to Coronary Artery Calcium Score and Degree of Stenosis on Coronary CT Angiography.Sisli Etfal Hastanesi tip bulteni · 2025Article
- The role of cardiac adipose tissue in coronary artery disease: a narrative review of cardiac imaging studies.Quantitative imaging in medicine and surgery · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Epicardial adipose tissue (EAT) is a metabolically activated beige adipose tissue, non-homogeneously surrounding the myocardium. Physiologically, EAT regulates toxic fatty acids, protects the coronary arteries against mechanical strain, regulates proinflammatory cytokines, stimulates the production of nitric oxide, reduces oxidative stress, and works as a thermogenic source against hypothermia. Conversely, EAT has pathologic paracrine interactions with the surrounded vessels, and might favour the onset of atrial fibrillation. In addition, initial atherosclerotic lesions can promote inflammation and trigger the EAT production of cytokines increasing vascular inflammation, which, in turn, may help the development of collateral vessels but also of self-stimulating, dysregulated inflammatory process, increasing coronary artery disease severity. Variations in EAT were also linked to metabolic syndrome. Echocardiography first estimated EAT measuring its thickness on the free wall of the right ventricle but does not allow accurate volumetric EAT estimates. Cardiac CT (CCT) and cardiac MR (CMR) allow for three-dimensional EAT estimates, the former showing higher spatial resolution and reproducibility but being limited by radiation exposure and long segmentation times, the latter being radiation-free but limited by lower spatial resolution and reproducibility, higher cost, and difficulties for obese patients. EAT radiodensity at CCT could to be related to underlying metabolic processes. The correlation between EAT and response to certain pharmacological therapies has also been investigated, showing promising results. In the future, semi-automatic or fully automatic techniques, machine/deep-learning methods, if validated, will facilitate research for various EAT measures and may find a place in CCT/CMR reporting.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.