SynthesisEuropean journal of clinical pharmacology2020

Impacts of metformin on tuberculosis incidence and clinical outcomes in patients with diabetes: a systematic review and meta-analysis.

What moved togetherboth groups pooled, not the treatment’s effect

Correlation, not cause

−49%−62% to −31%

Bigger than 9 in 10 for all-cause mortality

As reported

RR 0.51, 95% CI 0.38–0.69 · the paper's word: All-cause mortality

Correlation, not cause

−66%−80% to −43%

Bigger than almost all for all-cause mortality

As reported

RR 0.34, 95% CI 0.20–0.57 · the paper's word: All-cause mortality

the abstract, start to end

… among individuals with DM (RR = 0.51; 95% CI, 0.38-0.69, P ⩽ 0.001) and with TB-DM (RR = 0.34; 95% CI, 0.20-0.57, P ⩽ 0.001), …

← favours treatmentfavours comparator →

could be chance

All-cause mortality

RR 0.510.38–0.69

All-cause mortality

RR 0.340.20–0.57

MetforminAll-cause mortality

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