ArticleEuropean journal of nutrition2020
Changes of trace element status during aging: results of the EPIC-Potsdam cohort study.
Article in European journal of nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.
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Who cites it
43 citing papers in PubMed, 1 synthesis or guideline pooled it, 81 citations in OpenAlex.
- Blood copper and risk of cardiometabolic diseases: a Mendelian randomization study.Human molecular genetics · 2022Pooled it
- Functional Biomarkers for the Selenium Status in a Human Nutritional Intervention Study.Nutrients · 2020Trial
- Low serum selenium combined with SELENOP-autoantibodies are associated with persistent fatigue after SARS-CoV-2 infection.Redox biology · 2026Article
- Article
- Nutritional Strategies and Aging: Current Evidence and Future Directions.Molecules (Basel, Switzerland) · 2026Review
- Integrative bibliometric and transcriptomic analyses identify selenium-associated molecular signatures in the aging brain.Frontiers in aging neuroscience · 2026Article
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- Metals and metalloids concentrations in adults aged 50 and older from Mexico.Research square · 2025Article
- Arsenic, mercury, manganese, and lead exposure in Mexican adults aged 50 and older.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Association between serum copper concentration and type 2 diabetes mellitus in elderly people in Northeast China: a cross-sectional study.BMC geriatrics · 2025Article
- Advances in Mammalian Metallomics: New Insights into Metal Dynamics and Biological Significance.International journal of molecular sciences · 2025Review
- Selenium status markers and their relationship with anthropometric, glycemic, and inflammatory variables in institutionalized older adults.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2025Article
- Trace Mineral Imbalances in Global Health: Challenges, Biomarkers, and the Role of Serum Analysis.Nutrients · 2025Review
- Unveiling the Anti-Aging Potential of Marine Natural Bioproducts.Marine drugs · 2025Review
- Serum Zinc and Copper Concentrations and Dyslipidemia as Risk Factors of Cardiovascular Disease in Adults: Data Mining Techniques.Biological trace element research · 2025Article
- Distinct Clusters of Testosterone Levels, Symptoms, and Serum Trace Elements in Young Men: A Cross-Sectional Analysis.Nutrients · 2025Article
- Effects of Balanced Supplementation with Multiple Trace Elements on Oxidative Stress, Inflammation, and Immune Function in High-Fat Diet-Induced Rats.International journal of preventive medicine · 2025Article
- NRF2 and Thioredoxin Reductase 1 as Modulators of Interactions between Zinc and Selenium.Antioxidants (Basel, Switzerland) · 2024Article
- Subzero project: comparing trace element profiles of enriched mitochondria fractions from frozen and fresh liver tissue.Analytical and bioanalytical chemistry · 2024Article
- Postprandial Micronutrient Variability and Bioavailability: An Interventional Meal Study in Young vs. Old Participants.Nutrients · 2024Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
purposeWe aimed to evaluate age-dependent changes of six trace elements (TE) [manganese (Mn), iron (Fe), zinc (Zn), copper (Cu), iodine (I), and selenium (Se)] over a 20-year period.
methodsTE concentrations were determined using repeated serum samples taken at baseline and after 20 years of follow-up from 219 healthy participants of the EPIC-Potsdam study, using inductively coupled plasma tandem mass spectrometry. For each TE, absolute and relative differences were calculated between the two time points, as well as the proportion of individuals within normal reference ranges. Interdependence between age-related TE differences was investigated using principal component analysis (PCA). Relationships between selected factors (lifestyle, sociodemographic, anthropometric factors, and hypertension) and corresponding TE longitudinal variability were examined using multivariable linear regression models.
resultsMedian age of our study sample was 58.32 years (4.42) at baseline and 40% were females. Median Mn, Zn, Se concentrations and Se to Cu ratio significantly decreased during aging while median Fe, Cu, I concentrations and Cu to Zn ratio significantly increased. A substantial percentage of the participants, at both time points, had Zn concentrations below the reference range. The first PCA-extracted factor reflected the correlated decline in both Mn and Zn over time while the second factor reflected the observed (on average) increase in both Cu and I over time. Overall, none of the investigated factors were strong determinants of TE longitudinal variability, except possibly dietary supplement use, and alcohol use for Fe.
conclusionsIn conclusion, in this population-based study of healthy elderly, decrease in Mn, Zn, and Se concentrations and increase in Fe, Cu, and I concentrations were observed over 20 years of follow-up. Further research is required to investigate dietary determinants and markers of TE status as well as the relationships between TE profiles and the risk of age-related diseases.
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