Evidence map›Paper›PMID 31790273›Full record

ArticleAmerican journal of physiology. Gastrointestinal and liver physiology2020

IFN-γ and IL-17A regulate intestinal crypt production of CXCL10 in the healthy and inflamed colon.

Travis Walrath, Robert A Malizia, Xinjun Zhu, Stephen P Sharp, Shanti S D'Souza, Reynold Lopez-Soler, Brian Parr, Brittany Kartchner, Edward C Lee, Steven C Stain and 2 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of physiology. Gastrointestinal and liver physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.3field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 34 citations in OpenAlex.

  1. Article
  2. Review
  3. Impaired intestinal cell proliferation parallels increased senescence after burn injury in aged mice.American journal of physiology. Gastrointestinal and liver physiology · 2026
    Article
  4. Review
  5. Article
  6. Article
  7. Reducing the excessive inflammation after burn injury in aged mice by maintaining a healthier intestinal microbiome.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2024
    Article
  8. Review
  9. A Review on Role of Inflammation in Coronavirus Disease.Endocrine, metabolic & immune disorders drug targets · 2024
    Review
  10. Article
  11. Article
  12. Review
  13. Review
  14. Review
  15. Survival of Stem Cells and Progenitors in the Intestine Is Regulated by LPACellular and molecular gastroenterology and hepatology · 2022
    Article
  16. Article
  17. Article
  18. InVitro Models of Intestine Innate Immunity.Trends in biotechnology · 2021
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Travis WalrathDepartment of Immunology and Microbial Disease, Albany Medical College, Albany, New York.
Robert A MaliziaDepartment of Surgery, Albany Medical College, Albany, New York.
Xinjun ZhuDivision of Gastroenterology, Department of Internal Medicine, Albany Medical College, Albany, New York.
Stephen P SharpDepartment of Surgery, Albany Medical College, Albany, New York.
Shanti S D'SouzaDepartment of Immunology and Microbial Disease, Albany Medical College, Albany, New York.
Reynold Lopez-SolerDepartment of Surgery, Albany Medical College, Albany, New York.
Brian ParrCancer Research Center, University at Albany, Rensselaer, New York.
Brittany KartchnerDepartment of Immunology and Microbial Disease, Albany Medical College, Albany, New York.
Edward C LeeDepartment of Surgery, Albany Medical College, Albany, New York.
Steven C StainDepartment of Surgery, Albany Medical College, Albany, New York.
Yoichiro IwakuraInstitute for Biomedical Sciences, Tokyo University of Science, Noda, Chiba, Japan.
William O'ConnorDepartment of Immunology and Microbial Disease, Albany Medical College, Albany, New York.ORCID 0000-0002-2726-3121
Albany Medical Center Hospital · USTokyo University of Science · JPUniversity at Albany, State University of New York · US

Funding

Novel functions of TH17 cytokines: reciprocal regulation of non-canonical wntsR21AI117678 · NIAID · ALBANY MEDICAL COLLEGE · PI O'CONNOR, WILLIAM · 2016 to 2017
$435k
NIAID NIH HHS R21 AI117678
6 · The paper itself

Abstract

During intestinal inflammation, immature cells within the intestinal crypt are called upon to replenish lost epithelial cell populations, promote tissue regeneration, and restore barrier integrity. Inflammatory mediators including T

Indexed as

AnimalsCellular MicroenvironmentChemokine CXCL10ColitisColonDisease Models, AnimalInterferon-gammaInterleukin-17Intestinal MucosaMice, Inbred C57BLMice, Knockoutp38 Mitogen-Activated Protein KinasesPhosphorylationSignal TransductionSTAT1 Transcription FactorTissue Culture TechniquesChemokine CXCL10Cxcl10 protein, mouseIl17a protein, mouseInterferon-gammaInterleukin-17p38 Mitogen-Activated Protein KinasesRela protein, mouseStat1 protein, mouseSTAT1 Transcription FactorTranscription Factor RelAcolitiscolon cryptIFN-γIL-17Aintestinal epithelium

Identifiers

PMID31790273
PMCPMC7099492
OpenAlexW2992932596

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.