Evidence map›Paper›PMID 31792197›Full record

ArticleNature communications2019

Global redox proteome and phosphoproteome analysis reveals redox switch in Akt.

Zhiduan Su, James G Burchfield, Pengyi Yang, Sean J Humphrey, Guang Yang, Deanne Francis, Sabina Yasmin, Sung-Young Shin, Dougall M Norris, Alison L Kearney and 14 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
4.5field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 143 citations in OpenAlex.

  1. Exercise-induced lysosomal adaptations in skeletal muscle.Sports medicine and health science · 2026
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  12. The insulin signalling network.Nature metabolism · 2025
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 4 institutions in 2 countries.

Zhiduan SuCharles Perkins Centre, The University of Sydney, Sydney, NSW, 2006, Australia.
James G BurchfieldCharles Perkins Centre, The University of Sydney, Sydney, NSW, 2006, Australia.ORCID http://orcid.org/0000-0002-6609-6151
Pengyi YangCharles Perkins Centre, The University of Sydney, Sydney, NSW, 2006, Australia.ORCID http://orcid.org/0000-0003-1098-3138
Sean J HumphreyCharles Perkins Centre, The University of Sydney, Sydney, NSW, 2006, Australia.ORCID http://orcid.org/0000-0002-2666-9744
Guang YangCharles Perkins Centre, The University of Sydney, Sydney, NSW, 2006, Australia.
Deanne FrancisCharles Perkins Centre, The University of Sydney, Sydney, NSW, 2006, Australia.
Sabina YasminSchool of Physics, The University of Sydney, Sydney, NSW, 2006, Australia.
Sung-Young ShinDepartment of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, VIC, 3800, Australia.
Dougall M NorrisCharles Perkins Centre, The University of Sydney, Sydney, NSW, 2006, Australia.
Alison L KearneyCharles Perkins Centre, The University of Sydney, Sydney, NSW, 2006, Australia.
Miro A AstoreSchool of Physics, The University of Sydney, Sydney, NSW, 2006, Australia.
Jonathan ScavuzzoCharles Perkins Centre, The University of Sydney, Sydney, NSW, 2006, Australia.
Kelsey H Fisher-WellmanBrody School of Medicine, Physiology Department, East Carolina University, Greenville, NC, USA.
Qiao-Ping WangCharles Perkins Centre, The University of Sydney, Sydney, NSW, 2006, Australia.
Benjamin L ParkerCharles Perkins Centre, The University of Sydney, Sydney, NSW, 2006, Australia.
G Gregory NeelyCharles Perkins Centre, The University of Sydney, Sydney, NSW, 2006, Australia.
Fatemeh VafaeeCharles Perkins Centre, The University of Sydney, Sydney, NSW, 2006, Australia.ORCID http://orcid.org/0000-0002-7521-2417
Joyce ChiuThe Centenary Institute, Newtown, NSW, 2042, Australia.
Reichelle YeoThe Centenary Institute, Newtown, NSW, 2042, Australia.
Philip J HoggThe Centenary Institute, Newtown, NSW, 2042, Australia.ORCID http://orcid.org/0000-0001-6486-2863
Daniel J FazakerleyCharles Perkins Centre, The University of Sydney, Sydney, NSW, 2006, Australia.ORCID http://orcid.org/0000-0001-8241-2903
Lan K NguyenDepartment of Biochemistry and Molecular Biology, School of Biomedical Sciences, Monash University, Clayton, VIC, 3800, Australia.
Serdar KuyucakSchool of Physics, The University of Sydney, Sydney, NSW, 2006, Australia.
David E JamesCharles Perkins Centre, The University of Sydney, Sydney, NSW, 2006, Australia. david.james@sydney.edu.au.
The University of Sydney · AUCentenary Institute · AUAustralian Regenerative Medicine Institute · AUEast Carolina University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein oxidation sits at the intersection of multiple signalling pathways, yet the magnitude and extent of crosstalk between oxidation and other post-translational modifications remains unclear. Here, we delineate global changes in adipocyte signalling networks following acute oxidative stress and reveal considerable crosstalk between cysteine oxidation and phosphorylation-based signalling. Oxidation of key regulatory kinases, including Akt, mTOR and AMPK influences the fidelity rather than their absolute activation state, highlighting an unappreciated interplay between these modifications. Mechanistic analysis of the redox regulation of Akt identified two cysteine residues in the pleckstrin homology domain (C60 and C77) to be reversibly oxidized. Oxidation at these sites affected Akt recruitment to the plasma membrane by stabilizing the PIP

Indexed as

AdipocytesAnimalsCysteineHumansMiceOxidation-ReductionOxidative StressPhosphoproteinsPhosphorylationProtein DomainsProteomeProteomicsProto-Oncogene Proteins c-aktSignal TransductionTOR Serine-Threonine KinasesCysteinePhosphoproteinsProteomeProto-Oncogene Proteins c-aktTOR Serine-Threonine Kinases

Identifiers

PMID31792197
PMCPMC6889415
OpenAlexW2990325120

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.