← Metformin × all-cause mortality

SynthesisThe Cochrane database of systematic reviews2019

Metformin for prevention or delay of type 2 diabetes mellitus and its associated complications in persons at increased risk for the development of type 2 diabetes mellitus.

Kasper S Madsen et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedrandomised · 17,853 people · 2019

Randomised comparison

Reduced deaths

−50%−62% to −35%

Bigger than 9 in 10 for all-cause mortality

As reported

RR 0.50, 95% CI 0.38–0.65 · the paper's word: All-cause mortality

Range includes no effect

No clear effect on deaths

1.1×0.4× to 3×

Bigger than 3 in 10 for all-cause mortality

As reported

RR 1.11, 95% CI 0.41–3.01 · the paper's word: All-cause mortality

Range includes no effect

No clear effect on deaths

1.6×0.5× to 5.2×

Bigger than 8 in 10 for all-cause mortality

As reported

RR 1.61, 95% CI 0.50–5.23 · the paper's word: All-cause mortality

Range includes no effect

No clear effect on deaths

−20%−53% to +37%

Bigger than 6 in 10 for all-cause mortality

As reported

RR 0.80, 95% CI 0.47–1.37 · the paper's word: All-cause mortality

+2 more in the walkthrough ↓

Six numbers in the abstract

the abstract, start to end

… mortality was 7/1353 versus 7/1480 (RR 1.11, 95% CI 0.41 to 3.01; P = 0.83; 2833 participants, 5 trials; very low-quality evidence); incidence of T2DM was 324/1751 versus 529/1881 participants (RR 0.50, 95% CI 0.38 to 0.65; P < …

… mortality was 7/1278 versus 4/1272 (RR 1.61, 95% CI 0.50 to 5.23; P = 0.43; 2550 participants, 4 trials; very low-quality evidence); incidence of T2DM was 304/1455 versus 251/1505 (RR 0.80, 95% CI 0.47 to 1.37; P = 0.42; …

… of T2DM was 12/147 versus 7/148 (RR 1.72, 95% CI 0.72 to 4.14; P = 0.22; …

… of T2DM was 48/166 versus 53/166 (RR 0.55, 95% CI 0.10 to 2.92; P = 0.49; …

← favours treatmentfavours comparator →
could be chance
All-cause mortality
RR 1.110.41–3.01
All-cause mortality
RR 0.500.38–0.65
All-cause mortality
RR 1.610.50–5.23
All-cause mortality
RR 0.800.47–1.37
All-cause mortality
RR 1.720.72–4.14
All-cause mortality
RR 0.550.10–2.92
MetforminOther glucose-loweringAll-cause mortality
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Full record →Abstract, authors, funding and every citing paper · PMID 31794067