ReviewNature medicine2019
Chronic inflammation in the etiology of disease across the life span.
8 registry-linked trialsOpen access · bronzeAbstract readReview
In one paragraph
Review in Nature medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 8 registered trials, which are not on this map. Cited by 2,616 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
2,616citing papers in PubMed, 2 pooled it
252.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Grounded Brain: How Sleeping Grounded (Earthing) Affects Cognition and Personal Perceptions in Participants With Mild Cognitive Impairment Due to Alzheimer's Disease (MCI/AD)
Effects of a Wellbeing Intervention on Inflammation Through Reward and Threat Processes
Effects of Aerobic Exercise on Cancer-Related Biomarkers, Functional Capacity, Cognitive Status and Quality of Life in Women With Breast Cancer
NCT06635278 naactive not recruitingnot on this mapstarted 2024, after this paper: background citation
Effect of Mindfulness Meditation on Perceived Stress, Somatic Symptoms and Inflammatory Biomarkers Among Nurses
Desloratadine to Prevent Taxane-induced Peripheral Neuropathy in Patients With Breast Cancer (DETOXp)
NCT07248891 enrolling by invitationnot on this mapstarted 2025, after this paper: background citation
Comprehensive Study of Associated Factors With Type 2 Diabetes in Mexico: Protocol
Mindful Moms, Mindful Meals (MMMM): A Patient-Oriented Randomized Controlled Trial Testing the Effects of a Mindful Eating Intervention on Infant Feeding Practices
Mediterranean Diet Uptake and Nutrition on Child Health, Inflammation, and Early-life Symbiosis (MUNCHIES): A Randomized Controlled Trial
Who cites it
2,616 citing papers in PubMed, 2 syntheses or guidelines pooled it, 4,461 citations in OpenAlex.
- Multimorbidity and the risk of depression: a systematic review of cohort studies.Journal of global health · 2026Pooled it
- Dietary Patterns Associated With Anti-inflammatory Effects: An Umbrella Review of Systematic Reviews and Meta-analyses.Nutrition reviews · 2026Pooled it
- Effects of Acute Low- and Moderate-Dose Alcohol on Chronic Disease-Related Biomarkers in Healthy Light and Heavy Drinkers.Alcohol, clinical & experimental research · 2026Trial
- Baseline gut microbiome and metabolome profiles predict weight loss after a structured lifestyle intervention.Microbiome · 2026Trial
- Effect of anNutrients · 2026Trial
- Effect of aspirin on healthspan in community-dwelling older adults: the ASPirin in reducing events in the elderly study.Age and ageing · 2026Trial
- The Effects of a Powdered Meal Replacement on Inflammation, Gut Microbiota, and Metabolism in People With Excess Body Weight-A Randomized Controlled Trial.The Journal of nutrition · 2026Trial
- Pro/synbiotics reduce systemic inflammation and improve gut health in Kenyan infants: An open label, randomized, 4-arm, phase II trial.Cell reports. Medicine · 2026Trial
- Dietary Inflammatory Index and Cardiovascular Disease Risk in Australian Adults: A Secondary Analysis of the OLIVAUS Trial.Nutrients · 2026Trial
- Inhibition of IL-33 in Diabetic Kidney Disease: A Randomized, Placebo-Controlled Phase 2b Trial.Journal of the American Society of Nephrology : JASN · 2026Trial
- Gut microbiota in chronic inflammation: the interplay with lipid mediators.Gut microbes · 2026Review
- DNA methylation-based surrogate markers of C-reactive protein and their associations with health-related traits.GeroScience · 2026Article
- Review
- Association of CBC‑derived inflammation indices with prevalent CKD: a cross‑sectional analysis of a Chinese data set and NHANES.Annals of medicine · 2026Article
- Dissolving microneedles for inflammatory diseases: Advances in formulation strategies and therapeutic applications.International journal of pharmaceutics: X · 2026Review
- Balancing inflammation under stress: glucocorticoid regulation of innate immune pathways.Bioscience reports · 2026Review
- L-Arginine inhibits NLRP3 inflammasome activation.Nature metabolism · 2026Article
- Inflammaging reshapes the immune ecosystem in IgG4-related dacryoadenitis and sialadenitis.Rheumatology (Oxford, England) · 2026Article
- Food insecurity and cardiometabolic diseases among people with HIV in West Africa.AIDS (London, England) · 2026Article
- Inflammasomes in respiratory diseases: from disease pathogenesis to drug development and use of multi-omics.European respiratory review : an official journal of the European Respiratory Society · 2026Review
2,556 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors at 15 institutions in 7 countries.
David FurmanBuck Institute for Research on Aging, Novato, CA, USA. furmand@stanford.edu.ORCID http://orcid.org/0000-0002-3654-9519
Judith CampisiBuck Institute for Research on Aging, Novato, CA, USA.
Eric VerdinBuck Institute for Research on Aging, Novato, CA, USA.ORCID http://orcid.org/0000-0003-3703-3183
Pedro Carrera-BastosCenter for Primary Health Care Research, Lund University/Region Skåne, Skåne University Hospital, Malmö, Sweden.
Sasha TargIuve Inc., San Mateo, CA, USA.
Claudio FranceschiIRCCS Institute of Neurological Sciences of Bologna, Bologna, Italy.
Luigi FerrucciTranslational Gerontology Branch, National Institute on Aging, National Institutes of Health, Baltimore, MD, USA.
Derek W GilroyCentre for Clinical Pharmacology and Therapeutics, Division of Medicine, University College London, London, UK.
Alessio FasanoMassGeneral Hospital for Children, Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-2134-0261
Gary W MillerDepartment of Environmental Health Sciences, School of Public Health, Columbia University Medical Center, New York, NY, USA.
Andrew H MillerDepartment of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, GA, USA.
Alberto MantovaniHumanitas Clinical and Research Center, Rozzano, Milan, Italy.ORCID http://orcid.org/0000-0001-5578-236X
Cornelia M WeyandDivision of Immunology and Rheumatology, Department of Medicine, Stanford University, Stanford, CA, USA.ORCID http://orcid.org/0000-0003-2230-9802
Nir BarzilaiDepartments of Medicine and Genetics, Albert Einstein College of Medicine, New York, NY, USA.
Jorg J GoronzyPaul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA, USA.ORCID http://orcid.org/0000-0001-7670-1856
Thomas A RandoPaul F. Glenn Center for the Biology of Aging, Stanford University School of Medicine, Stanford, CA, USA.
Rita B EffrosDepartment of Pathology, University of California, Los Angeles, Los Angeles, CA, USA.
Alejandro LuciaFaculty of Sport Sciences, Universidad Europea de Madrid, Madrid, Spain.
Nicole KleinstreuerBiostatistics and Computational Biology Branch, Division of Intramural Research, National Institute of Environmental Health Sciences, National Institutes of Health, Department of Health and Human Services, Research Triangle Park, NC, USA.ORCID http://orcid.org/0000-0002-7914-3682
George M SlavichCousins Center for Psychoneuroimmunology and Department of Psychiatry and Biobehavioral Sciences, University of California, Los Angeles, Los Angeles, CA, USA.ORCID http://orcid.org/0000-0001-5710-3818
Buck Institute for Research on Aging · USNational Institutes of Health · USStanford University · USUniversity of California, Los Angeles · USAlbert Einstein College of Medicine · USColumbia University Irving Medical Center · USEmory University · USHarvard University · USHumanitas University · ITInstitute of Neurological Sciences · ITLund University · SEResearch Institute Hospital 12 de Octubre · ESUniversity College London · GBUniversity of California, San Francisco · USVA Palo Alto Health Care System · US
Funding
ROLE OF DIETARY CONSTITUENTS ON GENE EXPRESSION IN INTESTINAL EPITHELIUMP30DK040561 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI Elizabeth Austen Lawson, Takara Leah Stanley · 1994 to 2026
$31.6MWnt signaling in muscle stem cell agingP01AG036695 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Matteo Pellegrini · 2011 to 2026
$29.3MThe Role of Inflammation in Cardiovascular DiseaseP01HL129941 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARRISON, DAVID G · 2016 to 2020
$12.4MThe NOTCH Signaling Pathway in Large Vessel VasculitisR01HL117913 · NHLBI · STANFORD UNIVERSITY · PI WEYAND, CORNELIA M. · 2014 to 2025
$5.0MOligoclonal T Cell Expansion &Rheumatoid ArthritisR01AR042527 · NIAMS · STANFORD UNIVERSITY · PI WEYAND, CORNELIA M. · 1993 to 2022
$4.8MTelomere Damage Responses and Immune AgingR01AI108906 · NIAID · STANFORD UNIVERSITY · PI WEYAND, CORNELIA M. · 2014 to 2024
$4.0MMicrobiome-derived Metabolites Linked to Celiac Disease Onset in Infants at RiskR01DK104344 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI FASANO, ALESSIO · 2016 to 2020
$3.4MT Cell Immunity in Giant Cell ArteritisR01HL142068 · NHLBI · STANFORD UNIVERSITY · PI Cornelia M. Weyand · 2018 to 2026
$3.3MMolecular Regulation of Stem Cell QuiescenceR01AR073248 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI RANDO, THOMAS A. · 2018 to 2022
$2.6MComplement Components as Mediators of Cell and Tissue AgingR01AG055755 · NIA · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI RANDO, THOMAS A. · 2017 to 2021
$2.2MNeural, Inflammatory, and Genomic Mechanisms Underlying Risk for Depression in AdolescenceK08MH103443 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SLAVICH, GEORGE MICHAEL · 2015 to 2018
$772kNHLBI NIH HHS P01 HL129941NHLBI NIH HHS R01 HL117913NHLBI NIH HHS R01 HL142068NIAID NIH HHS R01 AI108906NIAMS NIH HHS R01 AR042527NIAMS NIH HHS R01 AR073248NIA NIH HHS P01 AG036695NIA NIH HHS R01 AG055755NIDDK NIH HHS P30 DK040561NIDDK NIH HHS R01 DK104344NIMH NIH HHS K08 MH103443Wellcome Trust
Abstract
Although intermittent increases in inflammation are critical for survival during physical injury and infection, recent research has revealed that certain social, environmental and lifestyle factors can promote systemic chronic inflammation (SCI) that can, in turn, lead to several diseases that collectively represent the leading causes of disability and mortality worldwide, such as cardiovascular disease, cancer, diabetes mellitus, chronic kidney disease, non-alcoholic fatty liver disease and autoimmune and neurodegenerative disorders. In the present Perspective we describe the multi-level mechanisms underlying SCI and several risk factors that promote this health-damaging phenotype, including infections, physical inactivity, poor diet, environmental and industrial toxicants and psychological stress. Furthermore, we suggest potential strategies for advancing the early diagnosis, prevention and treatment of SCI.
Indexed as
Autoimmune DiseasesCardiovascular DiseasesChronic DiseaseDiabetes MellitusHumansInflammationLife StyleLongevityNeoplasmsNeurodegenerative DiseasesNon-alcoholic Fatty Liver DiseaseRenal Insufficiency, ChronicRisk Factors
Identifiers
What Socratic holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
NCT05050812ClinicalTrials.gov
NCT06294145ClinicalTrials.gov
NCT06540612ClinicalTrials.gov
NCT06635278ClinicalTrials.gov
NCT07109817ClinicalTrials.gov
NCT07248891ClinicalTrials.gov
and 2 more above
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.