ArticleProceedings of the National Academy of Sciences of the United States of America2020
Equilibrium structure and deformation response of 2D kinetoplast sheets.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed.
- Organisation and dynamics of individual DNA segments in topologically complex genomes.Nucleic acids research · 2025Article
- Effect of Ring Composition on the Statics and Dynamics of Block Copolyelectrolyte Catenanes.Macromolecules · 2025Article
- Topological linking determines elasticity in limited valence networks.Nature materials · 2025Article
- Kinetoplast DNA: a polymer physicist's topological Olympic dream.Nucleic acids research · 2025Review
- From Bioreactor to Bulk Rheology: Achieving Scalable Production of Highly Concentrated Circular DNA.Advanced materials (Deerfield Beach, Fla.) · 2024Article
- Unraveling the Influence of Topology and Spatial Confinement on Equilibrium and Relaxation Properties of Interlocked Ring Polymers.Macromolecules · 2024Article
- Cluster Formation in Solutions of Polyelectrolyte Rings.ACS nano · 2023Article
- Quantum-inspired encoding enhances stochastic sampling of soft matter systems.Science advances · 2023Article
- Mixing Linear Polymers with Rings and Catenanes: Bulk and Interfacial Behavior.Macromolecules · 2023Article
- To thread or not to thread? Effective potentials and threading interactions between asymmetric ring polymers.Soft matter · 2022Article
- Topological gelation of reconnecting polymers.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Geometric Predictors of Knotted and Linked Arcs.ACS polymers Au · 2022Article
- Topological Friction and Relaxation Dynamics of Spatially Confined Catenated Polymers.ACS macro letters · 2022Article
- Conformational Freedom and Topological Confinement of Proteins in Biomolecular Condensates.Journal of molecular biology · 2022Review
- Human bloodsucking parasite in service of materials science.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
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Abstract
The considerable interest in two-dimensional (2D) materials and complex molecular topologies calls for a robust experimental system for single-molecule studies. In this work, we study the equilibrium properties and deformation response of a complex DNA structure called a kinetoplast, a 2D network of thousands of linked rings akin to molecular chainmail. Examined in good solvent conditions, kinetoplasts appear as a wrinkled hemispherical sheet. The conformation of each kinetoplast is dictated by its network topology, giving it a unique shape, which undergoes small-amplitude thermal fluctuations at subsecond timescales, with a wide separation between fluctuation and diffusion timescales. They deform elastically when weakly confined and swell to their equilibrium dimensions when the confinement is released. We hope that, in the same way that linear DNA became a canonical model system on the first investigations of its polymer-like behavior, kinetoplasts can serve that role for 2D and catenated polymer systems.
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