ArticleCurrent geriatrics reports2019
Integrating Frailty and Cognitive Phenotypes: Why, How, Now What?
Article in Current geriatrics reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- How gait influences frailty models and health-related outcomes in clinical-based and population-based studies: a systematic review.Journal of cachexia, sarcopenia and muscle · 2021Pooled it
- Construction and validation of a predictive model for reversible cognitive frailty in elderly people in nursing homes.BMC geriatrics · 2026Article
- The cross-sectional relationship of physical frailty and cognitive impairment in older Poles: analysis of the PolSenior2 data.European geriatric medicine · 2025Article
- Social isolation in relation to the incidence and dynamic progression of frailty in the oldest old: a trajectory analysis of a nationwide cohort.BMC public health · 2025Article
- Cognitive frailty: a useful concept or a source of confusion? Insights from a survey of European geriatricians.BMC geriatrics · 2025Article
- Association between cognitive reserve proxies and frailty phenotype: data from UK Biobank.GeroScience · 2025Article
- From frailty to resilience: exploring adaptive capacity and reserve in older adults-a narrative review.Frontiers in aging · 2025Review
- Essential New Complexity-Based Themes for Patient-Centered Diagnosis and Treatment of Dementia and Predementia in Older People: Multimorbidity and Multilevel Phenomenology.Journal of clinical medicine · 2024Review
- Screening of Hospitalized Elderly Patients for Frailty and Associated Co-morbid Conditions in Western Gujarat in India.Journal of family medicine and primary care · 2024Article
- Article
- Body Mass Index and Cognition: Associations Across Mid- to Late Life and Gender Differences.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Validation of the self-reported domains of the Edmonton Frail Scale in patients 65 years of age and older.BMC geriatrics · 2023Observational
- Physical Frailty and Cognitive Function among Older Chinese Adults: The Mediating Roles of Activities of Daily Living Limitations and Depression.The Journal of frailty & aging · 2023Article
- Longitudinal Changes of Cognition and Frailty With All-Cause and Cause-Specific Mortality in Chinese Older Adults: An 11-Year Cohort Study.Innovation in aging · 2023Article
- Aging metrics incorporating cognitive and physical function capture mortality risk: results from two prospective cohort studies.BMC geriatrics · 2022Article
- Progression of Physical Frailty and the Risk of All-Cause Mortality: Is There a Point of No Return?Journal of the American Geriatrics Society · 2021Observational
- The physical frailty syndrome as a transition from homeostatic symphony to cacophony.Nature aging · 2021Article
- U.S. National Profile of Older Adults with Cognitive Impairment Alone, Physical Frailty Alone, and Both.Journal of the American Geriatrics Society · 2020Article
- Article
- Principles and Issues for Physical Frailty Measurement and Its Clinical Application.The journals of gerontology. Series A, Biological sciences and medical sciences · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
Abstract
purpose of reviewThis review elucidates the concept of frailty in relationship to reserve and resilience, the relationships and shared pathophysiology between physical frailty and cognitive impairment, the theoretical underpinnings of three integrated phenotypes of physical and cognitive impairments, and the potential of incorporating biomarkers into phenotype refinement and validation. RECENT
findingsThe fact that frailty and cognitive impairment are associated and often coexist in older adults has led to the popular view of expanding the definition of frailty to include cognitive impairment. However, there is great variability in approaches to and assumptions regarding the integrated phenotypes of physical frailty and cognitive impairment. SUMMARY: The development of integrated frailty and cognitive phenotypes should explicate the types of frailty and cognitive impairment they intend to capture and prioritize the incorporation of biological theories that help determine shared and distinct pathways in the progression to physical and cognitive impairments.
Indexed as
Identifiers
31815092PMC6897328What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.