Evidence map›Paper›PMID 31819141›Full record

ArticleScientific reports2019

Notch signaling coordinates ommatidial rotation in the Drosophila eye via transcriptional regulation of the EGF-Receptor ligand Argos.

Yildiz Koca, Benjamin E Housden, William J Gault, Sarah J Bray, Marek Mlodzik

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 2 countries.

Yildiz KocaDept. of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.ORCID http://orcid.org/0000-0002-5243-9467
Benjamin E HousdenDept. of Physiology, Development and Neuroscience, University of Cambridge Downing Street, Cambridge, CB2 3DY, UK.
William J GaultDept. of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA.
Sarah J BrayDept. of Physiology, Development and Neuroscience, University of Cambridge Downing Street, Cambridge, CB2 3DY, UK.ORCID http://orcid.org/0000-0002-1642-599X
Marek MlodzikDept. of Cell, Developmental, and Regenerative Biology, Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place, New York, NY, 10029, USA. marek.mlodzik@mssm.edu.ORCID http://orcid.org/0000-0002-0628-3465
Icahn School of Medicine at Mount Sinai · USCity College of New York · USUniversity of Cambridge · GBUniversity of Exeter · GB

Funding

THE TISCH CANCER INSTITUTE - CANCER CENTER SUPPORT GRANTP30CA196521 · NCI · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Ramon E Parsons · 2015 to 2026
$35.4M
Retinal Patterning During Eye DevelopmentR01EY013256 · NEI · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI Marek Mlodzik · 2001 to 2026
$10.0M
Wnt/Frizzled-PCP signaling in development and diseaseR35GM127103 · NIGMS · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI Marek Mlodzik · 2018 to 2026
$5.6M
Medical Research Council G0800034NCI NIH HHS P30 CA196521NEI NIH HHS R01 EY013256NIGMS NIH HHS R35 GM127103U.S. Department of Health & Human Services | NIH | National Eye Institute (NEI) RO1 EY13256
6 · The paper itself

Abstract

In all metazoans, a small number of evolutionarily conserved signaling pathways are reiteratively used during development to orchestrate critical patterning and morphogenetic processes. Among these, Notch (N) signaling is essential for most aspects of tissue patterning where it mediates the communication between adjacent cells to control cell fate specification. In Drosophila, Notch signaling is required for several features of eye development, including the R3/R4 cell fate choice and R7 specification. Here we show that hypomorphic alleles of Notch, belonging to the N

Indexed as

AnimalsCell DifferentiationCell LineageCell PolarityDrosophila melanogasterDrosophila ProteinsErbB ReceptorsEyeEye ProteinsFrizzled ReceptorsMorphogenesisNerve Tissue ProteinsPhotoreceptor Cells, InvertebrateReceptors, Invertebrate PeptideReceptors, Notchaos protein, DrosophilaDrosophila ProteinsEgfr protein, DrosophilaErbB ReceptorsEye ProteinsFrizzled ReceptorsNerve Tissue ProteinsN protein, DrosophilaReceptors, Invertebrate PeptideReceptors, Notch

Identifiers

PMID31819141
PMCPMC6901570
OpenAlexW2991775083

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.