ArticleCell reports2019
Sphingosine-1-Phosphate Receptor 1 Activity Promotes Tumor Growth by Amplifying VEGF-VEGFR2 Angiogenic Signaling.
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Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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38citing papers in PubMed
2.8field-weighted citation impact, top 8% of its field
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Who cites it
38 citing papers in PubMed, 65 citations in OpenAlex.
- ERG-deficient endothelium identifies IL-8/CXCR2 axis as a therapeutic target for resolving neutrophilic lung vascular injury.JCI insight · 2026Article
- Sphingosine-1-phosphate promotes CD8 T cell exhaustion in breast cancer via exosomal transfer of TGFBR2.Cell death & disease · 2026Article
- Pan-cancer signaling landscape linked to endothelial and immune Sphingosine-1-phosphate receptor 1 (S1PR1) expression.In silico pharmacology · 2026Article
- Role of S1PR1 in VEGF-exosomes mediated resistance of hepatocellular carcinoma to anti-angiogenesis therapy.Cancer cell international · 2025Article
- Minimally Invasive Syringe-Injectable Hydrogel with Angiogenic Factors for Ischemic Stroke Treatment.Advanced healthcare materials · 2025Article
- Neutrophils physically interact with tumor cells to form a signaling niche promoting breast cancer aggressiveness.Nature cancer · 2025Article
- PI3K Signaling at the Crossroads of Lipid Metabolism and Cancer.Advances in experimental medicine and biology · 2025Review
- Zonation and ligand and dose dependence of sphingosine 1-phosphate receptor-1 signalling in blood and lymphatic vasculature.Cardiovascular research · 2024Article
- Emerging Roles for Sphingolipids in Cardiometabolic Disease: A Rational Therapeutic Target?Nutrients · 2024Review
- Oncogenic potential of SARS-CoV-2-targeting hallmarks of cancer pathways.Cell communication and signaling : CCS · 2024Review
- LRG1 loss effectively restrains glomerular TGF-β signaling to attenuate diabetic kidney disease.Molecular therapy : the journal of the American Society of Gene Therapy · 2024Article
- Multifaceted roles of lymphatic and blood endothelial cells in the tumor microenvironment of hepatocellular carcinoma: A comprehensive review.World journal of hepatology · 2024Review
- Parenchymal cues define Vegfa-driven venous angiogenesis by activating a sprouting competent venous endothelial subtype.Nature communications · 2024Article
- The emerging roles of sphingosine 1-phosphate and SphK1 in cancer resistance: a promising therapeutic target.Cancer cell international · 2024Review
- Sphingosine-1-phosphate promotes liver fibrosis in metabolic dysfunction-associated steatohepatitis.PloS one · 2024Article
- Sphingosine-1-Phosphate Signaling in Cardiovascular Diseases.Biomolecules · 2023Review
- Nucleolin promotes angiogenesis and endothelial metabolism along the oncofetal axis in the human brain vasculature.JCI insight · 2023Article
- Dual anti-angiogenic and anti-metastatic activity of myriocin synergistically enhances the anti-tumor activity of cisplatin.Cellular oncology (Dordrecht, Netherlands) · 2023Article
- Identifying key multifunctional components shared by critical cancer and normal liver pathways via SparseGMM.Cell reports methods · 2023Article
- FOXC2 Promotes Vasculogenic Mimicry in Ovarian Cancer.Cancers · 2022Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 2 countries.
Vijay Avin Balaji RagunathraoDepartment of Pharmacology and The Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, IL 60612, USA.
Mumtaz AnwarDepartment of Pharmacology and The Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, IL 60612, USA.
Md Zahid AkhterDepartment of Pharmacology and The Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, IL 60612, USA.
Alejandra ChavezDepartment of Pharmacology and The Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, IL 60612, USA.
De Yu MaoDepartment of Physiology, The University of Illinois College of Medicine, Chicago, IL 60612, USA.
Viswanathan NatarajanDepartment of Pharmacology and The Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, IL 60612, USA; Department of Medicine, The University of Illinois College of Medicine, Chicago, IL 60612, USA.
Sribalaji LakshmikanthanBlood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA.
Magdalena Chrzanowska-WodnickaBlood Research Institute, Blood Center of Wisconsin, Milwaukee, WI 53226, USA.
Arkadiusz Z DudekDepartment of Medicine, The University of Illinois College of Medicine, Chicago, IL 60612, USA.
Lena Claesson-WelshDepartment of Immunology, Genetics and Pathology, Rudbeck Laboratory, Science for Life Laboratory, Uppsala University, 751 85 Uppsala, Sweden.
Jan K KitajewskiDepartment of Physiology, The University of Illinois College of Medicine, Chicago, IL 60612, USA.
Kishore K WaryDepartment of Pharmacology and The Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, IL 60612, USA.
Asrar B MalikDepartment of Pharmacology and The Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, IL 60612, USA.
Dolly MehtaDepartment of Pharmacology and The Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, IL 60612, USA. Electronic address: dmehta@uic.edu.
Illinois College · USUniversity of Illinois Chicago · USUniversity of Illinois Urbana-Champaign · USVersiti Blood Center of Wisconsin · USScience for Life Laboratory · SE
Funding
TRPC6 Regulation of Lung Endothelial Barrier FunctionP01HL060678 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MALIK, ASRAR B. · 2000 to 2020
$40.1MTRAINING PROGRAM IN LUNG BIOLOGY AND PATHOBIOLOGYT32HL007829 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DOLLY MEHTA · 1995 to 2026
$15.6MNotch in Angiogenesis and Vascular BiologyR01HL112626 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI Jan K. Kitajewski · 2012 to 2026
$6.3MFocal Adhesion Kinase Regulation of Lung Vascular Permeability and EdemagenesisR01HL084153 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI MEHTA, DOLLY · 2007 to 2022
$5.4MRap1 in VEGF signaling in endothelial cellsR01HL111582 · NHLBI · VERSITI WISCONSIN, INC. · PI CHRZANOWSKA, MAGDALENA · 2012 to 2019
$3.3MNHLBI NIH HHS P01 HL060678NHLBI NIH HHS R01 HL084153NHLBI NIH HHS R01 HL111582NHLBI NIH HHS R01 HL112626NHLBI NIH HHS T32 HL007829
Abstract
The vascular endothelial growth factor-A (VEGF-A)-VEGFR2 pathway drives tumor vascularization by activating proangiogenic signaling in endothelial cells (ECs). Here, we show that EC-sphingosine-1-phosphate receptor 1 (S1PR1) amplifies VEGFR2-mediated angiogenic signaling to enhance tumor growth. We show that cancer cells induce S1PR1 activity in ECs, and thereby, conditional deletion of S1PR1 in ECs (EC-S1pr1
Indexed as
Signal TransductionAnimalsCells, CulturedEndothelial CellsEndothelium, VascularHEK293 CellsHumansMaleMiceNeoplasms, ExperimentalNeovascularization, PathologicNeuropeptidesProto-Oncogene Proteins c-ablrac1 GTP-Binding ProteinSphingosine-1-Phosphate ReceptorsVascular Endothelial Growth Factor AKdr protein, mouseNeuropeptidesProto-Oncogene Proteins c-ablrac1 GTP-Binding ProteinRac1 protein, mouseS1pr1 protein, mouseSphingosine-1-Phosphate ReceptorsVascular Endothelial Growth Factor AVascular Endothelial Growth Factor Receptor-2angiogenesisc-Abl1endothelial cellsRac1S1PS1PR1tumor growthtumor vascularizationVEGF-AVEGFR2 phosphorylation
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LicenceCC BY-NC-ND
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.