ArticleJournal of sports science & medicine2019
Cardiac Damage Biomarkers and Heart Rate Variability Following a 118-Km Mountain Race: Relationship with Performance and Recovery.
Article in Journal of sports science & medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Recovery of Linear and Nonlinear Heart Rate Variability Metrics After Short-Term Moderate versus Vigorous Intensity Exercise: A Cross-Sectional Randomized Cross-Over Study.European journal of sport science · 2025Trial
- Immediate and 24-h post-marathon cardiac troponin T is associated with relative exercise intensity.European journal of applied physiology · 2020Trial
- Muscle, Neuromuscular, and Cardiac Damage in Trail Running: A Systematic Review.Muscles (Basel, Switzerland) · 2026Review
- Artificial intelligence and sports genomics: advancing precision sports science and athletic performance.Frontiers in sports and active living · 2026Review
- Fractal correlation properties of heart rate variability and respiratory frequency as measures of endurance exercise durability.European journal of applied physiology · 2025Article
- Prediction of perioperative complications in colorectal cancerWorld journal of gastrointestinal surgery · 2025Article
- Is There a Role of Beetroot Consumption on the Recovery of Oxidative Status and Muscle Damage in Ultra-Endurance Runners?Nutrients · 2024Observational
- Effects of Long-Term Endurance Exercise on Cardiac Morphology, Function, and Injury Indicators among Amateur Marathon Runners.International journal of environmental research and public health · 2023Article
- Effect of an Ultra-Endurance Event on Cardiovascular Function and Cognitive Performance in Marathon Runners.Frontiers in physiology · 2022Article
- Fractal Correlation Properties of Heart Rate Variability as a Biomarker for Intensity Distribution and Training Prescription in Endurance Exercise: An Update.Frontiers in physiology · 2022Review
- Influence of Female Sex Hormones on Ultra-Running Performance and Post-Race Recovery: Role of Testosterone.International journal of environmental research and public health · 2021Article
- Measurement of Cancer-Related Fatigue Based on Heart Rate Variability: Observational Study.Journal of medical Internet research · 2021Observational
- Fractal correlation properties of heart rate variability as a biomarker of endurance exercise fatigue in ultramarathon runners.Physiological reports · 2021Article
- Impact of Plasma Oxidative Stress Markers on Post-race Recovery in Ultramarathon Runners: A Sex and Age Perspective Overview.Antioxidants (Basel, Switzerland) · 2021Article
- Changes in Factors Regulating Serum Sodium Homeostasis During Two Ultra-Endurance Mountain Races of Different Distances: 69km vs. 121km.Frontiers in physiology · 2021Article
- The Consequences of Training and Competition to the Musculoskeletal System in Ultramarathon Runners: A Narrative Review.Frontiers in physiology · 2021Review
- Analysis of food and fluid intake in elite ultra-endurance runners during a 24-h world championship.Journal of the International Society of Sports Nutrition · 2020Article
- Effect of mountain ultramarathon distance competition on biochemical variables, respiratory and lower-limb fatigue.PloS one · 2020Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to assess the release of cardiac damage biomarkers jointly with cardiac autonomic modulation after a mountain ultramarathon. Such knowledge and the possible relationship of these markers with race time is of primary interest to establish possible recommendations upon athletes' recovery and return to training following these competitions. Forty six athletes enrolled in the Penyagolosa Trails CSP115 race (118 km and a total positive elevation of 5439 m) took part in the study. N-terminal pro-brain natriuretic peptide (NT-proBNP) and high-sensitive cardiac troponin T (hs-TNT) concentrations as well as linear and nonlinear heart rate variability (HRV) were evaluated before and after the race. NT-proBNP and hs-TNT significantly increased post-race; fifty percent of the finishers surpassed the Upper Reference Limit (URL) for hs-TNT while 87% exceeded the URL for NT-proBNP. Overall and vagally-mediated HRV were diminished and cardiac autonomic modulation became less complex and more predictable following the race. More pronounced vagal modulation decreases were associated with higher levels of postexertional NT-proBNP. Moreover, rise in hs-TNT and NT-proBNP was greater among faster runners, while pre-race overall and vagally-mediated HRV were correlated with finishing time. Participation in a 118-km ultratrail induces an acute release of cardiac damage biomarkers and a large alteration of cardiac autonomic modulation. Furthermore, faster runners were those who exhibited a greater rise in those cardiac damage biomarkers. In light of these findings, an appropriate recovery period after ultraendurance races appears prudent and particularly important among better performing athletes. At the same time, HRV analysis is shown as a promising tool to assess athletes' readiness to perform at their maximum level in an ultraendurance race.
Indexed as
Identifiers
31827345PMC6873135W2970222911What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.