Evidence map›Paper›PMID 31827424›Full record

ArticleFrontiers in cellular neuroscience2019

Structure and Function of Cochlear Gap Junctions and Implications for the Translation of Cochlear Gene Therapies.

Xuewen Wu, Wenjuan Zhang, Yihui Li, Xi Lin

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.2field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 17 citations in OpenAlex.

  1. Review
  2. Recent Progress in Mechanism-Based Therapies forInternational journal of molecular sciences · 2026
    Review
  3. Article
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Article
  10. Molecular therapy. Methods & clinical development · 2021
    Article
  11. Review
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Xuewen WuDepartment of Otolaryngology, Head-Neck and Surgery, Xiangya Hospital of Central South University, Changsha, China.
Wenjuan ZhangDepartment of Otolaryngology, Wuhan Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.
Yihui LiDepartment of Pharmacy, Changsha Hospital of Traditional Medicine, Changsha, China.
Xi LinDepartment of Otolaryngology, Emory University School of Medicine, Atlanta, GA, United States.
Emory University · USWuhan Union Hospital · CN

Funding

Role of connexins in cochlear functionsR01DC006483 · NIDCD · EMORY UNIVERSITY · PI LIN, XI · 2006 to 2015
$3.4M
Gene Therapy for Treating Human Genetic Deafness Tested in Animal ModelsR01DC014496 · NIDCD · EMORY UNIVERSITY · PI ZHENG, JAMES Q · 2016 to 2020
$2.4M
NIDCD NIH HHS R01 DC006483NIDCD NIH HHS R01 DC014496
6 · The paper itself

Abstract

Connexins (Cxs) are ubiquitous membrane proteins that are found throughout vertebrate organs, acting as building blocks of the gap junctions (GJs) known to play vital roles in the normal function of many organs. Mutations in Cx genes (particularly

Indexed as

cochleaconnexindeafnessgap junctiongene therapystructure and function

Identifiers

PMID31827424
PMCPMC6892400
OpenAlexW2984582510

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.