ArticleJournal of endocrinology and diabetes2019
Type 2 Diabetes Predicts Increased Risk of Neurodegenerative Complications in Veterans Suffering Traumatic Brain Injury.
Article in Journal of endocrinology and diabetes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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Who cites it
11 citing papers in PubMed, 18 citations in OpenAlex.
- Article
- Neuroprotective Effects of a Serotonin Receptor Peptide Following ShamEndocrinology, diabetes and metabolism journal · 2023Article
- Reversal of Early Increased Anxiety-Like Behavior in the Zucker FattyEndocrinology, diabetes and metabolism journal · 2023Article
- Pulmonary infection in traumatic brain injury patients undergoing tracheostomy: predicators and nursing care.BMC pulmonary medicine · 2022Article
- Differential association of baseline body weight and body-weight loss with neurological deficits, histology, and death after repetitive closed head traumatic brain injury.Neuroscience letters · 2022Article
- Gene Expression Changes in a Model Neuron Cell Line Exposed to Autoantibodies from Patients with Traumatic Brain Injury and/or Type 2 Diabetes.Molecular neurobiology · 2021Article
- Medical Comorbidities Associated With Outcomes in Patients With Traumatic Epidural Hematomas.Cureus · 2021Article
- Bypassing TBI: Metabolic Surgery and the Link between Obesity and Traumatic Brain Injury-a Review.Obesity surgery · 2020Review
- Circulating Agonist Autoantibody to 5-Hydroxytryptamine 2A Receptor in Lean and Diabetic Fatty Zucker Rat Strains.Endocrinology, diabetes and metabolism journal · 2020Article
- Role of Insulin in Neurotrauma and Neurodegeneration: A Review.Frontiers in neuroscience · 2020Review
- Genetic Diversity Influences Response and Outcome to Blast Traumatic Brain Injury in a Murine Model.Neurotrauma reportsArticle
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
aimsObese type 2 diabetes and traumatic brain injury are associated with persistent peripheral and neuro-inflammation, respectively. We tested whether adult type 2 diabetes increased the hazard rate for neurodegeneration complications following traumatic brain injury.
methodsRetrospective chart review of patients treated at the Veterans Affairs New Jersey Healthcare System between 2016-2019 and having a diagnosis of prior traumatic brain injury was performed in adult veterans, age 50 years or older. Cox proportional hazards regression analysis was used to identify risk factors predictive of an increased risk of neurodegeneration, i.e. worsening major depression, dementia or Parkinson's disease following traumatic brain injury.
resultsType 2 diabetes predicted a nearly three-fold increased hazard ratio (HR = 2.95, 95% CI 1.15-7.56, P =0.02) for the occurrence of worsening major depression, dementia or Parkinson's disease in eighty adults age 50 years or older who had experienced prior traumatic brain injury. After adjusting for other covariates, hypertension (HR= 4.15, 95% CI 1.21-14.29, P =0.02) was significant and body mass index (HR=1.14, 95% CI 0.99-1.30; P=0.06) modestly significant predictors of the risk for the time to first occurrence of the composite neurodegenerative outcome.
conclusionType 2 diabetes, hypertension and higher body mass index increase the hazard for the occurrence of worsening depression, Parkinson's disease and dementia following traumatic brain injury in middle-aged and older adults.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.