ArticleNeurobiology of stress2019
Hippocampal connectivity in the aftermath of acute social stress.
Article in Neurobiology of stress, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Functional MRI Techniques Suggesting that the Stress System Interacts with Three Large Scale Core Brain Networks to Help Coordinate the Adaptive Response: A Systematic Review.Current neuropharmacology · 2024Pooled it
- Neural Mechanisms and Brain Alterations in Orofacial Pain: A Narrative Review of Human Neuroimaging.Diagnostics (Basel, Switzerland) · 2026Review
- Neurological Responses to Scented Insects via Olfactory Stimulation: A Controlled fMRI Study.Insects · 2026Article
- Social valence dictates sex differences in identity recognition.Translational psychiatry · 2026Article
- Article
- The double-edged sword of the hippocampus-ventromedial prefrontal cortex resting-state connectivity in stress susceptibility and resilience: A prospective study.Neurobiology of stress · 2023Article
- Pre-COVID brain functional connectome features prospectively predict emergence of distress symptoms after onset of the COVID-19 pandemic.Psychological medicine · 2023Article
- Altered Resting-State functional connectivity in the anterior and posterior hippocampus in Post-traumatic stress disorder: The central role of the anterior hippocampus.NeuroImage. Clinical · 2023Article
- Article
- Inter-relationships between changes in stress, mindfulness, and dynamic functional connectivity in response to a social stressor.Scientific reports · 2022Article
- Brain Functional Network Analysis of Patients with Primary Angle-Closure Glaucoma.Disease markers · 2022Article
- The functional connectome predicts feeling of stress on regular days and during the COVID-19 pandemic.Neurobiology of stress · 2021Article
- Molecular and neurocircuitry mechanisms of social avoidance.Cellular and molecular life sciences : CMLS · 2021Review
- Topography of hippocampal connectivity with sensorimotor cortex revealed by optimizing smoothing kernel and voxel size.PloS one · 2021Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hippocampus is a core brain region that responds to stress. Previous studies have found a dysconnectivity between hippocampus and other brain regions under acute and chronic stress. However, whether and how acute social stress influences the directed connectivity patterns from and to the hippocampus remains unclear. In this study, using a within-subject design and Granger causal analysis (GCA), we investigated the alterations of resting state effective connectivity from and to hippocampal subregions after an acute social stressor (the Trier Social Stress Test). Participants were engaged in stress and control conditions spaced approximately one month apart. Our findings showed that stress altered the information flows in the thalamus-hippocampus-insula/midbrain circuit. The changes in this circuit could also predict with high accuracy the stress and control conditions at the subject level. These hippocampus-related brain networks have been documented to be involved in emotional information processing and storage, as well as habitual responses. We speculate that alterations of the effective connectivity between these brain regions may be associated with the registering and encoding of threatening stimuli under stress. Our investigation of hippocampal functional connectivity at a subregional level may help elucidate the functional neurobiology of stress-related psychiatric disorders.
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