Evidence map›Paper›PMID 31836539›Full record

ArticleJournal of molecular and cellular cardiology2020

Angiotensin peptide synthesis and cyclic nucleotide modulation in sympathetic stellate ganglia.

Emma N Bardsley, Oliver C Neely, David J Paterson

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of molecular and cellular cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.8field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 10 citations in OpenAlex.

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  9. Circulating prorenin: its molecular forms and plasma concentrations.Hypertension research : official journal of the Japanese Society of Hypertension · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Emma N BardsleyWellcome Trust OXION Initiative in Ion Channels and Disease, Oxford, UK; Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK; British Heart Foundation, Centre of Research Excellence, UK. Electronic address: emmabardsley91@gmail.com.
Oliver C NeelyBurdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK; British Heart Foundation, Centre of Research Excellence, UK.
David J PatersonWellcome Trust OXION Initiative in Ion Channels and Disease, Oxford, UK; Burdon Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics, University of Oxford, Oxford OX1 3PT, UK; British Heart Foundation, Centre of Research Excellence, UK. Electronic address: david.paterson@dpag.ox.ac.uk.
British Heart Foundation · GBUniversity of Oxford · GBWellcome Trust · GB

Funding

Comprehensive Structural and Functional Mapping of the Mammalian Cardiac Nervous SystemOT2OD023848 · OD · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI EFIMOV, IGOR R, FOWLKES, CHARLESS · 2016 to 2021
$21.4M
British Heart Foundation RG/17/14/33085NIH HHS OT2 OD023848Wellcome TrustWellcome Trust 105409/Z/14/Z
6 · The paper itself

Abstract

Chronically elevated angiotensin II is a widely-established contributor to hypertension and heart failure via its action on the kidneys and vasculature. It also augments the activity of peripheral sympathetic nerves through activation of presynaptic angiotensin II receptors, thus contributing to sympathetic over-activity. Although some cells can synthesise angiotensin II locally, it is not known if this machinery is present in neurons closely coupled to the heart. Using a combination of RNA sequencing and quantitative real-time polymerase chain reaction, we demonstrate evidence for a renin-angiotensin synthesis pathway within human and rat sympathetic stellate ganglia, where significant alterations were observed in the spontaneously hypertensive rat stellate ganglia compared with Wistar stellates. We also used Förster Resonance Energy Transfer to demonstrate that administration of angiotensin II and angiotensin 1-7 peptides significantly elevate cyclic guanosine monophosphate in the rat stellate ganglia. Whether the release of angiotensin peptides from the sympathetic stellate ganglia alters neurotransmission and/or exacerbates cardiac dysfunction in states associated with sympathetic over activity remains to be established.

Indexed as

AdultAgedAngiotensinsAnimalsCyclic GMPFemaleGene Expression RegulationHumansMaleMiddle AgedModels, BiologicalNucleotides, CyclicPrincipal Component AnalysisRats, Inbred SHRRats, WistarReninAngiotensinsCyclic GMPNucleotides, CyclicReninRNA, MessengerAngiotensinAutonomic nervous systemHypertensionStellate gangliaSympathetic

Identifiers

PMID31836539
PMCPMC7049903
OpenAlexW2995061015

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.