ArticleThe Journal of allergy and clinical immunology2020
Noncanonical autophagy in dermal dendritic cells mediates immunosuppressive effects of UV exposure.
Article in The Journal of allergy and clinical immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 13 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 19 citations in OpenAlex.
- The autophagy protein RUBCNL/PACER represses RIPK1 kinase-dependent apoptosis and necroptosis.Autophagy · 2024Article
- The role and research progress of tumor-associated macrophages in cervical cancer.American journal of cancer research · 2024Review
- Unveiling the interplay between mutational signatures and tumor microenvironment: a pan-cancer analysis.Frontiers in immunology · 2023Article
- Article
- Skin Injury Activates a Rapid TRPV1-Dependent Antiviral Protein Response.The Journal of investigative dermatology · 2022Article
- Autophagy: Guardian of Skin Barrier.Biomedicines · 2022Review
- Dendritic cell PIK3C3/VPS34 controls the pathogenicity of CNS autoimmunity independently of LC3-associated phagocytosis.Autophagy · 2022Article
- Interactions of Autophagy and the Immune System in Health and Diseases.Autophagy reports · 2022Article
- What's the deal with efferocytosis and asthma?Trends in immunology · 2021Review
- The IFN-γ-IDO1-kynureine pathway-induced autophagy in cervical cancer cell promotes phagocytosis of macrophage.International journal of biological sciences · 2021Article
- Guidelines for Regulated Cell Death Assays: A Systematic Summary, A Categorical Comparison, A Prospective.Frontiers in cell and developmental biology · 2021Review
- LC3-Associated Phagocytosis (LAP): A Potentially Influential Mediator of Efferocytosis-Related Tumor Progression and Aggressiveness.Frontiers in oncology · 2020Review
- Inhibition of LC3-associated phagocytosis in COPD and in response to cigarette smoke.Therapeutic advances in respiratory diseaseArticle
Corrections and comments
- Retraction · 2022-09-15Concerns/Issues about Image · Date of Article and/or Notice Unknown · Error in Data · Error in Image · Error in Results and/or Conclusions · Falsification/Fabrication of Data · Unreliable Results and/or Conclusions · · unknown date of retraction, html page overwrite, date entered 9/15/2022;
- Commented on by
- Retracted
Authors and funding
13 authors at 5 institutions in 1 country.
Funding
Abstract
backgroundControl of the inflammatory response is critical to maintaining homeostasis, and failure to do so contributes to the burden of chronic inflammation associated with several disease states. The mechanisms that underlie immunosuppression, however, remain largely unknown. Although defects in autophagy machinery have been associated with inflammatory pathologic conditions, we now appreciate that autophagic components participate in noncanonical pathways distinct from classical autophagy. We have previously demonstrated that LC3-associated phagocytosis (LAP), a noncanonical autophagic process dependent on Rubicon (rubicon autophagy regulator [RUBCN]), contributes to immunosuppression.
objectiveWe used Rubcn
methodsFlow cytometry and transcriptional analysis were used to measure immune cell infiltration and activation in the skin of Rubcn
resultsHere, we demonstrate that LAP is required for UV-induced immunosuppression and that UV exposure induces a broadly anti-inflammatory transcriptional program dependent on Rubicon. Rubcn
conclusionsLAP functions to limit the immune response and is critical in maintaining the balance between homeostasis and inflammation.
Indexed as
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What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.