Evidence map›Paper›PMID 31839488›Full record

ArticleCell metabolism2020

NTS Catecholamine Neurons Mediate Hypoglycemic Hunger via Medial Hypothalamic Feeding Pathways.

Iltan Aklan, Nilufer Sayar Atasoy, Yavuz Yavuz, Tayfun Ates, Ilknur Coban, Fulya Koksalar, Gizem Filiz, Iskalen Cansu Topcu, Merve Oncul, Pelin Dilsiz and 9 more

Open access · greenAbstract read
In one paragraph

Article in Cell metabolism, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers.

0numbers the graph read from it
0cells of the map it votes in
102citing papers in PubMed
5.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

102 citing papers in PubMed, 146 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. The critical role of gut-brain signalling in eating behaviour and obesity.Nature reviews. Gastroenterology & hepatology · 2026
    Review
  6. Review
  7. Article
  8. Article
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  11. Article
  12. Article
  13. Article
  14. Brain Nutrient Sensing: A Unifying Framework.Annual review of physiology · 2026
    Review
  15. Review
  16. Complex dynamics of glutamate-induced calcium responses in astrocytes from the nucleus of the solitary tract of mice.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas · 2026
    Article
  17. Review
  18. Article
  19. Article
  20. Review

42 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 3 countries.

Iltan AklanDepartment of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa, USA.
Nilufer Sayar AtasoyDepartment of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa, USA.
Yavuz YavuzDepartment of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa, USA; Department of Physiology, School of Medicine, Yeditepe University, Istanbul, Turkey.
Tayfun AtesDepartment of Physiology, School of Medicine, Regenerative and Restorative Medical Research Center (REMER), Istanbul Medipol University, Istanbul, Turkey.
Ilknur CobanDepartment of Physiology, School of Medicine, Regenerative and Restorative Medical Research Center (REMER), Istanbul Medipol University, Istanbul, Turkey.
Fulya KoksalarDepartment of Physiology, School of Medicine, Regenerative and Restorative Medical Research Center (REMER), Istanbul Medipol University, Istanbul, Turkey.
Gizem FilizDepartment of Physiology, School of Medicine, Regenerative and Restorative Medical Research Center (REMER), Istanbul Medipol University, Istanbul, Turkey.
Iskalen Cansu TopcuDepartment of Physiology, School of Medicine, Yeditepe University, Istanbul, Turkey.
Merve OnculDepartment of Physiology, School of Medicine, Regenerative and Restorative Medical Research Center (REMER), Istanbul Medipol University, Istanbul, Turkey.
Pelin DilsizDepartment of Physiology, School of Medicine, Regenerative and Restorative Medical Research Center (REMER), Istanbul Medipol University, Istanbul, Turkey.
Utku CebeciogluDepartment of Physiology, School of Medicine, Regenerative and Restorative Medical Research Center (REMER), Istanbul Medipol University, Istanbul, Turkey.
Muhammed Ikbal AlpDepartment of Physiology, School of Medicine, Regenerative and Restorative Medical Research Center (REMER), Istanbul Medipol University, Istanbul, Turkey.
Bayram YilmazDepartment of Physiology, School of Medicine, Yeditepe University, Istanbul, Turkey.
Deborah R DavisDepartment of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa, USA.
Karolina HajdukiewiczLaboratory of Animal Models, Neurobiology Center, Nencki Institute of Experimental Biology, Warsaw, Poland.
Kenji SaitoDepartment of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa, USA.
Witold KonopkaLaboratory of Animal Models, Neurobiology Center, Nencki Institute of Experimental Biology, Warsaw, Poland.
Huxing CuiDepartment of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa, USA.
Deniz AtasoyDepartment of Neuroscience and Pharmacology, Roy J. and Lucille A. Carver College of Medicine, Iowa Neuroscience Institute, University of Iowa, Iowa City, Iowa, USA. Electronic address: deniz-atasoy@uiowa.edu.
Istanbul Medipol University · TRUniversity of Iowa · USYeditepe University · TRInstytut Biologii Doświadczalnej im. Marcelego Nenckiego · PL

Funding

Role of the brain Renin-Angiotensin Sys. in Cardiovas and Metabolic RegulationP01HL084207 · NHLBI · UNIVERSITY OF IOWA · PI SIGMUND, CURT DANIEL · 2007 to 2022
$30.2M
Lateral Hypothalamic Regulation of Sympathetic Nerve Activity and Blood PressureR01HL127673 · NHLBI · UNIVERSITY OF IOWA · PI CUI, HUXING · 2016 to 2020
$2.0M
Behavioral characterization of humanized mouse model of eating disorderR21MH109920 · NIMH · UNIVERSITY OF IOWA · PI CUI, HUXING · 2016 to 2017
$419k
NHLBI NIH HHS P01 HL084207NHLBI NIH HHS R01 HL127673NIMH NIH HHS R21 MH109920
6 · The paper itself

Abstract

Glucose is the essential energy source for the brain, whose deficit, triggered by energy deprivation or therapeutic agents, can be fatal. Increased appetite is the key behavioral defense against hypoglycemia; however, the central pathways involved are not well understood. Here, we describe a glucoprivic feeding pathway by tyrosine hydroxylase (TH)-expressing neurons from nucleus of solitary tract (NTS), which project densely to the hypothalamus and elicit feeding through bidirectional adrenergic modulation of agouti-related peptide (AgRP)- and proopiomelanocortin (POMC)-expressing neurons. Acute chemogenetic inhibition of arcuate nucleus (ARC)-projecting NTS

Indexed as

Appetite RegulationAgouti-Related ProteinAnimalsFemaleHypoglycemiaHypothalamusMaleMiceMice, Inbred C57BLNeuronsSolitary NucleusAgouti-Related ProteinAgrp protein, mouseAgRParcuate nucleuscatecholaminefeedinghypoglycemiahypoglycemic unawarenessnorepinephrineNTStyrosine hydroxylase

Identifiers

PMID31839488
PMCPMC9017597
OpenAlexW2995624894

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.