Evidence map›Paper›PMID 31849608›Full record

ArticleFrontiers in cellular neuroscience2019

Decoupling the Effects of the Amyloid Precursor Protein From Amyloid-β Plaques on Axonal Transport Dynamics in the Living Brain.

Christopher S Medina, Taylor W Uselman, Daniel R Barto, Frances Cháves, Russell E Jacobs, Elaine L Bearer

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular neuroscience, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.5field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Reconfiguration of brain-wide neural activity after early life adversity.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Reconfiguration of brain-wide neural activity after early life adversity.bioRxiv : the preprint server for biology · 2025
    Article
  3. Article
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Christopher S MedinaDepartment of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM, United States.
Taylor W UselmanDepartment of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM, United States.
Daniel R BartoDepartment of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM, United States.
Frances ChávesDepartment of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM, United States.
Russell E JacobsZilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, United States.
Elaine L BearerDepartment of Pathology, University of New Mexico Health Sciences Center, Albuquerque, NM, United States.
University of New Mexico · USCalifornia Institute of Technology · US

Funding

FAIR Data Competency and Machine Learning Readiness for Biomedical ScientistsK12GM088021 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI REBECCA S. HARTLEY, Diane Lidke · 2009 to 2026
$16.4M
Live imaging of brain circuitry in mouse models of PTSDR01MH096093 · NIMH · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BEARER, ELAINE L · 2012 to 2016
$2.8M
Using Transport to Map the BrainR01NS062184 · NINDS · UNIVERSITY OF NEW MEXICO · PI BEARER, ELAINE L · 2009 to 2010
$1.5M
Molecular mechanisms of anterograde transportR01NS046810 · NINDS · BROWN UNIVERSITY · PI BEARER, ELAINE L · 2004 to 2007
$1.1M
NIGMS NIH HHS K12 GM088021NIMH NIH HHS R01 MH096093NINDS NIH HHS R01 NS046810NINDS NIH HHS R01 NS062184
6 · The paper itself

Abstract

Amyloid precursor protein (APP) is the precursor to Aβ plaques. The cytoplasmic domain of APP mediates attachment of vesicles to molecular motors for axonal transport. In APP-KO mice, transport of Mn

Indexed as

amyloid precursor protein (APP)CA3 of the hippocampuscholinergic neuronsdentate gyrus and septal nucleifast microtubule-based axonal transportmanganese-enhanced magnetic resonance imaging (MEMRI)Swedish and Indiana mutation (APPSwInd)transgenic mice for Alzheimer’s disease investigation

Identifiers

PMID31849608
PMCPMC6901799
OpenAlexW2991794052

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.