Evidence map›Paper›PMID 31861101›Full record

ArticleBiosensors2019

Carbon Nanotube-Based Electrochemical Biosensor for Label-Free Protein Detection.

Jesslyn Janssen, Mike Lambeta, Paul White, Ahmad Byagowi

Abstract read
In one paragraph

Article in Biosensors, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jesslyn JanssenDepartment of Biological Sciences, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Mike LambetaDepartment of Physics and Astronomy, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Paul WhiteDepartment of Electrical and Computer Engineering, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.
Ahmad ByagowiDepartment of Electrical and Computer Engineering, University of Manitoba, Winnipeg, MB R3T 2N2, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is a growing need for biosensors that are capable of efficiently and rapidly quantifying protein biomarkers, both in the biological research and clinical setting. While accurate methods for protein quantification exist, the current assays involve sophisticated techniques, take long to administer and often require highly trained personnel for execution and analysis. Herein, we explore the development of a label-free biosensor for the detection and quantification of a standard protein. The developed biosensors comprise carbon nanotubes (CNTs), a specific antibody and cellulose filtration paper. The change in electrical resistance of the CNT-based biosensor system was used to sense a standard protein, bovine serum albumin (BSA) as a proof-of-concept. The developed biosensors were found to have a limit of detection of 2.89 ng/mL, which is comparable to the performance of the typical ELISA method for BSA quantification. Additionally, the newly developed method takes no longer than 10 min to perform, greatly reducing the time of analysis compared to the traditional ELISA technique. Overall, we present a versatile, affordable, simplified and rapid biosensor device capable of providing great benefit to both biological research and clinical diagnostics.

Indexed as

Biosensing TechniquesElectrochemical TechniquesAnimalsCattleEnzyme-Linked Immunosorbent AssayNanotubes, CarbonSerum Albumin, BovineNanotubes, CarbonSerum Albumin, Bovinebovine serum albumincarbon nanotubeselectrochemical biosensorsELISAlabel-free biosensorspoint-of-care diagnosticsSWCNT

Identifiers

PMID31861101
PMCPMC6956173

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.