Evidence map›Paper›PMID 31861691›Full record

ReviewInternational journal of molecular sciences2019

Are Leukaemic Stem Cells Restricted to a Single Cell Lineage?

Geoffrey Brown, Lucía Sánchez, Isidro Sánchez-García

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Zebrafish models of acute leukemias: Current models and future directions.Wiley interdisciplinary reviews. Developmental biology · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Geoffrey BrownSchool of Biomedical Sciences, Institute of Clinical Sciences, University of Birmingham, Birmingham B15 2TT, UK.
Lucía SánchezSchool of Law, University of Salamanca, 37007 Salamanca, Spain.
Isidro Sánchez-GarcíaExperimental Therapeutics and Translational Oncology Program, Instituto de Biología Moleculary Celular del Cáncer, CSIC/Universidad de Salamanca, 37007 Salamanca, Spain.
Universidad de Salamanca · ESUniversity of Birmingham · GB

Funding

European Commission 315902
6 · The paper itself

Abstract

Cancer-stem-cell theory states that most, if not all, cancers arise from a stem/uncommitted cell. This theory revolutionised our view to reflect that cancer consists of a hierarchy of cells that mimic normal cell development. Elegant studies of twins who both developed acute lymphoblastic leukaemia in childhood revealed that at least two genomic insults are required for cancer to develop. These 'hits' do not appear to confer a growth advantage to cancer cells, nor do cancer cells appear to be better equipped to survive than normal cells. Cancer cells created by investigators by introducing specific genomic insults generally belong to one cell lineage. For example, transgenic mice in which the LIM-only 2 (

Indexed as

Adaptor Proteins, Signal TransducingAnimalsCell LineageFusion Proteins, bcr-ablHematopoietic Stem CellsHumansLeukemiaLIM Domain ProteinsMiceMice, TransgenicNeoplastic Stem CellsProto-Oncogene ProteinsAdaptor Proteins, Signal TransducingFusion Proteins, bcr-ablLIM Domain ProteinsLMO2 protein, humanProto-Oncogene Proteinscancerhaematopoiesisleukaemialineage decision makingoncogenesstem cells

Identifiers

PMID31861691
PMCPMC6981580
OpenAlexW2995413165

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.