Evidence map›Paper›PMID 31875545›Full record

ArticleCell reports2019

Astrocytes Amplify Neuronal Dendritic Volume Transmission Stimulated by Norepinephrine.

Chun Chen, ZhiYing Jiang, Xin Fu, Diankun Yu, Hai Huang, Jeffrey G Tasker

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
3.3field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Article
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  4. Chemoarchitectural studies of the rat hypothalamus and zona incerta.bioRxiv : the preprint server for biology · 2025
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  6. Adenosine ABiological psychiatry · 2025
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  7. Direct Modulation of CRH Nerve Terminal Function by Noradrenaline and Corticosterone.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Review
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  14. Article
  15. Review
  16. Article
  17. Article
  18. Multiplexed Membrane Signaling by Glucocorticoids.Current opinion in endocrine and metabolic research · 2022
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Chun ChenDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA.
ZhiYing JiangDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA.
Xin FuDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA; Tulane Brain Institute, Tulane University, New Orleans, LA 70118, USA.
Diankun YuDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA; Tulane Brain Institute, Tulane University, New Orleans, LA 70118, USA.
Hai HuangDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA; Tulane Brain Institute, Tulane University, New Orleans, LA 70118, USA.
Jeffrey G TaskerDepartment of Cell and Molecular Biology, Tulane University, New Orleans, LA 70118, USA; Tulane Brain Institute, Tulane University, New Orleans, LA 70118, USA. Electronic address: tasker@tulane.edu.
Tulane University · US

Funding

Stress Plasticity of CRH NeuronsR01MH119283 · NIMH · TULANE UNIVERSITY OF LOUISIANA · PI TASKER, JEFFREY G · 2019 to 2025
$2.7M
Synaptic mechanisms of auditory information processingR01DC016324 · NIDCD · TULANE UNIVERSITY OF LOUISIANA · PI Hai Huang · 2018 to 2026
$2.5M
Cellular Plasticity and HPA Axis DysfunctionR01MH069879 · NIMH · TULANE UNIVERSITY OF LOUISIANA · PI TASKER, JEFFREY G · 2004 to 2009
$1.9M
NIDCD NIH HHS R01 DC016324NIMH NIH HHS R01 MH069879NIMH NIH HHS R01 MH119283
6 · The paper itself

Abstract

In addition to their support role in neurotransmitter and ion buffering, astrocytes directly regulate neurotransmission at synapses via local bidirectional signaling with neurons. Here, we reveal a form of neuronal-astrocytic signaling that transmits retrograde dendritic signals to distal upstream neurons in order to activate recurrent synaptic circuits. Norepinephrine activates α

Indexed as

Action PotentialsAdrenergic alpha-AgonistsAnimalsAstrocytesCell CommunicationChannelrhodopsinsCorticotropin-Releasing HormoneDendritesGABAergic Neuronsgamma-Aminobutyric AcidGene Expression RegulationGlutamic AcidHypothalamusMaleMiceMice, TransgenicAdrenergic alpha-AgonistsChannelrhodopsinsCorticotropin-Releasing Hormonegamma-Aminobutyric AcidGlutamic AcidNorepinephrineReceptors, CorticotropinastrocyteCRHgliahypothalamusnoradrenalinenorepinephrineparaventricular nucleusstressvasopressin

Identifiers

PMID31875545
PMCPMC7010232
OpenAlexW2998211798

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.