Evidence map›Paper›PMID 31879331›Full record

ArticleAJNR. American journal of neuroradiology2020

Characterization of Carotid Plaque Components by Quantitative Susceptibility Mapping.

M Azuma, K Maekawa, A Yamashita, K Yokogami, M Enzaki, Z A Khant, H Takeshima, Y Asada, Y Wang, T Hirai

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AJNR. American journal of neuroradiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.6field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. QSM Throughout the Body.Journal of magnetic resonance imaging : JMRI · 2023
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 3 countries.

M AzumaFrom the Departments of Radiology (M.A., Z.A.K., T.H.) minako_azuma@med.miyazaki-u.ac.jp.ORCID 0000-0002-4837-4197
K MaekawaPathology (K.M., A.Y.).ORCID 0000-0002-5177-6242
A YamashitaPathology (K.M., A.Y.).ORCID 0000-0001-5487-7594
K YokogamiNeurosurgery (K.Y., H.T., Y.A.), Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.ORCID 0000-0003-1320-9383
M EnzakiRadiology Section (M.E.), University of Miyazaki Hospital, Miyazaki, Japan.ORCID 0000-0001-5188-0640
Z A KhantFrom the Departments of Radiology (M.A., Z.A.K., T.H.).ORCID 0000-0003-4826-1472
H TakeshimaNeurosurgery (K.Y., H.T., Y.A.), Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.ORCID 0000-0002-5699-7642
Y AsadaNeurosurgery (K.Y., H.T., Y.A.), Faculty of Medicine, University of Miyazaki, Miyazaki, Japan.ORCID 0000-0001-5105-2159
Y WangDepartment of Radiology (Y.W.), Weill Medical College of Cornell University, New York, New York.ORCID 0000-0003-1404-8526
T HiraiFrom the Departments of Radiology (M.A., Z.A.K., T.H.).ORCID 0000-0003-1480-2197
University of Miyazaki · JPAnna Needs Neuroblastoma Answers · USMaharaja Yeshwantrao Hospital · INCornell University · USUniversity of Miyazaki Hospital · JP

Funding

No-Gd MRI for Monitoring Disease Status in Multiple SclerosisR01NS105144 · NINDS · WEILL MEDICAL COLL OF CORNELL UNIV · PI GAUTHIER, SUSAN A, GUPTA, AJAY · 2018 to 2022
$2.8M
NINDS NIH HHS R01 NS105144
6 · The paper itself

Abstract

background and purposeIntraplaque hemorrhage in the carotid artery is related to an increased risk of cerebrovascular ischemic events. We aimed to investigate whether quantitative susceptibility mapping can characterize carotid artery plaque components and quantify the severity of intraplaque hemorrhage. MATERIALS AND

methodsFor this ex vivo quantitative susceptibility mapping study, 9 carotid endarterectomy specimens were imaged on a 3T MR imaging scanner using a 3D multi-echo gradient-echo sequence and a microscopy coil. The samples were examined histologically using immunostains, including glycophorin A and Prussian blue. The areas of erythrocytes, iron deposits, calcification, and fibrous matrices observed on stained sections were compared with quantitative susceptibility mapping findings and their mean susceptibility values.

resultsIntraplaque hemorrhage and iron deposits were observed only in areas hyperintense on quantitative susceptibility mapping; calcifications and fibrous matrices were prevalent in hypointense areas. The mean susceptibility values for necrotic cores with intraplaque hemorrhage but no iron deposits, cores with iron deposits but no intraplaque hemorrhage, cores without either intraplaque hemorrhage or iron deposits, and cores with calcification were 188 ± 51, 129 ± 49, -11 ± 17, and -158 ± 78 parts per billion, respectively. There was a significant difference in the mean susceptibility values among the 4 histologic components (

conclusionsOur findings suggest that quantitative susceptibility mapping can characterize the composition of carotid plaques and quantify the degree of intraplaque hemorrhage and iron deposits.

Indexed as

AgedAged, 80 and overCarotid StenosisFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedPlaque, Atherosclerotic

Identifiers

PMID31879331
PMCPMC7015197
OpenAlexW2998442961

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.