ArticleOrthopaedic surgery2020
Bone Turnover Markers and Bone Mineral Density to Predict Osteoporotic Fractures in Older Women: A Retrospective Comparative Study.
Article in Orthopaedic surgery, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 34 citations in OpenAlex.
- Integration of Multi-Scale Predictive Tools of Bone Fragility: A Structural and Material Property Perspective.Materials (Basel, Switzerland) · 2025Review
- Article
- Plasma serotonin precursors and metabolites as diagnostic and therapeutic biomarkers for osteoporosis in postmenopausal women.Biomolecules & biomedicine · 2025Article
- Assessment of bone status and bone turnover in pediatric patients with familiar hypomagnesemia with hypercalciuria and nephrocalcinosis.Scientific reports · 2025Article
- Association between bone turnover markers and FRAX predicted fracture risk in Chinese adults: a cross-sectional study.BMC musculoskeletal disorders · 2025Article
- Risk factors for nonunion of osteoporotic vertebral compression fracture: a case‒control study.BMC musculoskeletal disorders · 2024Article
- A comprehensive approach for osteoporosis detection through chest CT analysis and bone turnover markers: harnessing radiomics and deep learning techniques.Frontiers in endocrinology · 2024Article
- Correlation Between Bone Metabolism Indices and Osteoporotic Thoracolumbar Vertebrae Fracture in Postmenopausal Women.International journal of general medicine · 2024Article
- The Effect of Denosumab in Elderly Patients Regarding Bone Density and Fracture Risk.Journal of bone metabolism · 2023Article
- Allolobophora caliginosa coelomic fluid and extract alleviate glucocorticoid-induced osteoporosis in mice by suppressing oxidative stress and regulating osteoblastic/osteoclastic-related markers.Scientific reports · 2023Article
- Risk factors of primary and recurrent fractures in postmenopausal osteoporotic Chinese patients: A retrospective analysis study.BMC women's health · 2022Article
- Serum calcium-phosphorus product for predicting the risk of osteoporotic vertebral compression fractures in elderly patients: a retrospective observational study.Journal of orthopaedic surgery and research · 2022Observational
- Value of Biochemical Indexes of Bone Metabolism in Predicting Osteoporotic Lumbar Fractures.Applied bionics and biomechanics · 2022Article
- Bone-turnover biomarkers as potential prognostic factors in sudden sensorineural hearing loss: A prospective cohort study.Frontiers in neurology · 2022Article
- A patient with Turner syndrome received the percutaneous vertebroplasty seven times: a case report and literature review.European journal of medical research · 2021Review
- Association between bone turnover markers and the risk of imminent recurrent osteoporotic fracture.Medicine internationalArticle
- Interplay of Vitamin D, Inflammation, and Bone Health in Emirati Patients with Type 2 Diabetes: A Cross-sectional Study.Saudi journal of medicine & medical sciencesArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo investigate the clinical significance of the detection of bone mineral density (BMD) and bone turnover markers (BTM) in older women with osteoporosis, and to compare their predictive power for osteoporotic fractures (OF).
methodsIn this retrospective study, 96 patients with OF and 107 patients with osteoporosis who were hospitalized in the Department of Orthopedics at the First Affiliated Hospital of Chengdu Medical College were examined from October 2017 to February 2019. All selected patients were divided into either the fracture group (96 cases, 47.3%) or the non-fracture group (107 cases, 52.7%). BMD was measured by dual-energy X-ray absorptiometry (DXA). BTM were detected by electrochemical luminescence: aminoterminal propeptide of type I procollagen (PINP), β-cross-linked C-telopeptide of type I collagen (β-CTX), and molecular fragment of osteocalcin N terminal (N-MID). Bone metabolism-related indicators were detected, including alkaline phosphatase (ALP), calcium (Ca), and phosphorus (P). Independent-samples t-tests were used to compare the measurement data between the two groups, one-way ANOVA to compare the gaps between groups, and binary logistic regression to analyze the correlation of BMD and BTM with OF.
resultsThere were no significant differences in age, weight, height, body mass index, age, and time of menopause between the two groups. There were a total of 71 cases (35.0%) in group A (60-70 years), 80 cases (39.4%) in group B (71-80 years), and 52 cases (25.6%) in group C (81-90 years). The fracture group was compared with the non-fracture group for BMD in the lumbar (0.75 ± 0.05 vs 0.88 ± 0.13, 0.75 ± 0.16 vs 0.87 ± 0.09, 0.74 ± 0.21 vs 0.87 ± 0.12 g/cm
conclusionOsteoporotic older women, with lower bone density and higher β-CTX, are more likely to incur OF. β-CTX is better than BMD at predicting OF and can help in its management and in implementing interventions in high-risk populations.
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