ArticleScientific reports2019
Diverse sensitivities of TRPA1 from different mosquito species to thermal and chemical stimuli.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 31 citations in OpenAlex.
- Mosquito heat and humidity detection in host seeking and oviposition behavior.Current opinion in neurobiology · 2026Review
- Understanding animal temperature sensation: from molecular thermosensors to physiological impacts.Science China. Life sciences · 2026Review
- Involvement of Multiple Ion Channels and Receptors in Mediating the Insecticidal and Repellent Actions of Limonene.International journal of molecular sciences · 2025Article
- Agonism of mosquito and human transient receptor potential ankyrin 1 (TRPA1) channels by the natural drimane sesquiterpene cinnamodial.bioRxiv : the preprint server for biology · 2025Article
- Exploiting TRP channel diversity in insects: a pathway to next-generation pest management.Archives of toxicology · 2025Review
- Heat activation desensitizes Aedes aegypti transient receptor potential ankyrin 1 (AaTRPA1) to chemical agonists that repel mosquitoes.Pesticide biochemistry and physiology · 2025Article
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- Functional relationship between peripheral thermosensation and behavioral thermoregulation.Frontiers in neural circuits · 2024Review
- Avoidance of thiazoline compound depends on multiple sensory pathways mediated by TrpA1 and ORs inFrontiers in molecular neuroscience · 2023Article
- Noxious chemical discrimination byCurrent research in insect science · 2023Article
- TRPA1-mediated repellency behavior in the red flour beetle Tribolium castaneum.Scientific reports · 2022Article
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- Plasmodium metabolite HMBPP stimulates feeding of main mosquito vectors on blood and artificial toxic sources.Communications biology · 2021Article
- The irritant receptor TRPA1 mediates the mosquito repellent effect of catnip.Current biology : CB · 2021Article
- Comparisons in temperature and photoperiodic-dependent diapause induction between domestic and wild mulberry silkworms.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Temperature and odors profoundly affect the behavior of animals. Transient receptor potential channel, subfamily A, member 1 (TRPA1) functions as a polymodal nociceptor for sensing both vital environmental cues in insects. Mosquitoes are recognized as disease vectors, and many efforts have been devoted to investigations of their host-seeking behaviors and repellents. However, the physiological characteristics of mosquito TRPA1 have not been systematically studied. We identified multiple alternative splice variants of the TrpA1 gene from Anopheles gambiae, Anopheles stephensi, Aedes aegypti and Culex pipiens pallens mosquitoes. And we performed comparative analyses of the responses of mosquito TRPA1s to heat or chemical stimuli with calcium-imaging and whole-cell patch-clamp methods. Comparison of TRPA1 among four mosquito species from different thermal niches revealed that TRPA1 of Culex pipiens pallens inhabiting the temperate zone had a lower temperature threshold for heat-evoked activation, which was supported by the in vivo heat-avoidance test. Notably, the chemosensitivity of mosquito TRPA1 channels revealed differences not only between variants but also among species. Moreover, we discovered three novel mosquito TRPA1 agonists. Thermal niches selection and evolutionary trajectories significantly affect the functional properties of mosquito TRPA1, which represents a hallmark of the behaviors that may permit the design of improved mosquito control methods.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.