Evidence map›Paper›PMID 31886416›Full record

ArticleCommunications biology2019

Genetic variation drives seasonal onset of hibernation in the 13-lined ground squirrel.

Katharine R Grabek, Thomas F Cooke, L Elaine Epperson, Kaitlyn K Spees, Gleyce F Cabral, Shirley C Sutton, Dana K Merriman, Sandra L Martin, Carlos D Bustamante

Open access · goldAbstract read
In one paragraph

Article in Communications biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
7.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Pronounced Neuroplasticity in the Primary Visual Cortex of the 13-Lined Ground Squirrel during Hibernation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026
    Article
  3. Article
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  7. Article
  8. Review
  9. Article
  10. The fructose survival hypothesis for obesity.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Review
  11. Review
  12. Article
  13. Review
  14. Characterization of Retinal Development in 13-Lined Ground Squirrels.Translational vision science & technology · 2022
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 8 institutions in 3 countries.

Katharine R Grabek1Department of Genetics and Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA USA.ORCID 0000-0003-4082-5624
Thomas F Cooke3Department of Genetics, Stanford University School of Medicine, Stanford, CA USA.
L Elaine Epperson5Center for Genes, Environment and Health, National Jewish Health, Denver, CO, USA.ORCID 0000-0002-6715-1001
Kaitlyn K Spees3Department of Genetics, Stanford University School of Medicine, Stanford, CA USA.
Gleyce F Cabral3Department of Genetics, Stanford University School of Medicine, Stanford, CA USA.ORCID 0000-0002-6213-5037
Shirley C Sutton7Department of Genetics and Department of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA USA.ORCID 0000-0001-9044-3224
Dana K Merriman8Department of Biology, University of Wisconsin Oshkosh, Oshkosh, WI USA.ORCID 0000-0003-2780-0772
Sandra L Martin9Department of Cell and Developmental Biology, University of Colorado School of Medicine, Aurora, CO USA.
Carlos D Bustamante1Department of Genetics and Department of Biomedical Data Science, Stanford University School of Medicine, Stanford, CA USA.
Stanford University · USChan Zuckerberg Initiative (United States) · USFauna and Flora International · GBNational Jewish Health · USUniversidade Federal do Pará · BRUniversity of Colorado Denver · USUniversity of Wisconsin–Oshkosh · USWhitehead Institute for Biomedical Research · US

Funding

Biomarkers for the two phase switches of mammalian hibernationR01HL089049 · NHLBI · UNIVERSITY OF COLORADO DENVER · PI MARTIN, SANDRA L · 2008 to 2011
$1.5M
NHLBI NIH HHS R01 HL089049
6 · The paper itself

Abstract

Hibernation in sciurid rodents is a dynamic phenotype timed by a circannual clock. When housed in an animal facility, 13-lined ground squirrels exhibit variation in seasonal onset of hibernation, which is not explained by environmental or biological factors. We hypothesized that genetic factors instead drive variation in timing. After increasing genome contiguity, here, we employ a genotype-by-sequencing approach to characterize genetic variation in 153 ground squirrels. Combined with datalogger records (

Indexed as

Genetic VariationSeasonsAnimalsFemaleGenetic LociGenetics, PopulationGenomeGenomicsGeographyHibernationInheritance PatternsMalePolymorphism, Single NucleotideSciuridaeComputational biology and bioinformaticsGenetics

Identifiers

PMID31886416
PMCPMC6925185
OpenAlexW2995468567

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.