Trial reportPediatric diabetes2020
Evaluation of the longitudinal change in health behavior profiles across treatment groups in the TODAY clinical trial.
Trial report in Pediatric diabetes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00081328. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Studies to Treat Or Prevent Pediatric Type 2 Diabetes (STOPP-T2D) Treatment Options for Type 2 Diabetes in Adolescents and Youth (TODAY) Clinical Trial
Who cites it
7 citing papers in PubMed, 10 citations in OpenAlex.
- Response to Comment on Chen et al. Circulating Metabolite Biomarkers of Glycemic Control in Youth-Onset Type 2 Diabetes. Diabetes Care 2024;47:1597-1607.Diabetes care · 2025Article
- Risk of developing chronic kidney disease in young-onset Type 2 diabetes in Korea.Scientific reports · 2023Article
- From Metabolic Syndrome to Type 2 Diabetes in Youth.Children (Basel, Switzerland) · 2023Review
- ISPAD Clinical Practice Consensus Guidelines 2022: Exercise in children and adolescents with diabetes.Pediatric diabetes · 2022Article
- Characteristics of Glycemic Control and Long-Term Complications in Patients with Young-Onset Type 2 Diabetes.Endocrinology and metabolism (Seoul, Korea) · 2022Article
- Young-onset type 2 diabetes in South Korea: a review of the current status and unmet need.The Korean journal of internal medicine · 2021Review
- Physical activity and cardiometabolic health in adolescents with type 2 diabetes: a cross-sectional study.BMJ open diabetes research & care · 2021Article
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
backgroundIndividual health behaviors (ie, eating habits and sedentary lifestyle) are associated with type 2 diabetes (T2D). Health behavior profiles specific to adolescents with T2D have not been described.
objectiveTo identify health behavior profiles in adolescents with T2D and examine how these profiles change over time.
methodsDiet (via food frequency questionnaire) and activity behaviors (via 3-day physical activity recall) examined at baseline, 6 months, and 24 months from participants in the the Treatment Options for T2D in Adolescents and Youth (TODAY) study were used for this analysis. Latent profile analysis identified profiles of health behaviors within three time points, and latent transition probabilities were estimated to examine the change from baseline to 6 months (n = 450) and baseline to 24 months (n = 415). Multinomial logistic regressions were used to examine if the assigned TODAY treatment group (Metformin [Met], Met + Rosiglitazone [Rosi], or Met + Lifestyle) predicted change in health behavior profiles.
resultsThree profiles emerged: "most sedentary," "healthy eaters," and "active and eat most." At 6 months, 50% of males and 29% of females in the Met + Lifestyle treatment group improved in their health behavior profile. Among males only, the Met + Lifestyle treatment group were more likely to improve their profiles from baseline to 6 months (P = .01).
conclusionsThree health behavior profiles emerged and shifted over time. A high quality, lifestyle intervention had little effect on improving health behavior profiles. Optimizing outcomes in youth with T2D might require more robust and multifaceted interventions beyond family-level lifestyle, including more extensive psychosocial intervention, novel medication regimen, or bariatric surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.