Evidence map›Paper›PMID 31890733›Full record

ArticleMolecular therapy. Methods & clinical development2019

Preclinical Evaluation of a Cell-Based Gene Therapy Using the Sleeping Beauty Transposon System in Choroidal Neovascularization.

Maria Hernandez, Sergio Recalde, Laura Garcia-Garcia, Jaione Bezunartea, Csaba Miskey, Sandra Johnen, Sabine Diarra, Attila Sebe, Juan Roberto Rodriguez-Madoz, Severine Pouillot and 9 more

Open access · goldAbstract read
In one paragraph

Article in Molecular therapy. Methods & clinical development, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Stargardt macular dystrophy and therapeutic approaches.The British journal of ophthalmology · 2024
    Review
  5. Review
  6. Article
  7. Enhanced Biosafety of theBiomolecules · 2023
    Article
  8. Article
  9. Article
  10. Review
  11. Review
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 10 institutions in 4 countries.

Maria HernandezExperimental Ophthalmology Laboratory, Ophthalmology, Clínica Universidad de Navarra, IdiSNA, Pamplona, Spain.
Sergio RecaldeExperimental Ophthalmology Laboratory, Ophthalmology, Clínica Universidad de Navarra, IdiSNA, Pamplona, Spain.
Laura Garcia-GarciaExperimental Ophthalmology Laboratory, Ophthalmology, Clínica Universidad de Navarra, IdiSNA, Pamplona, Spain.
Jaione BezunarteaExperimental Ophthalmology Laboratory, Ophthalmology, Clínica Universidad de Navarra, IdiSNA, Pamplona, Spain.
Csaba MiskeyDivision of Medical Biotechnology, Paul Ehrlich-Institut, 63225 Langen, Germany.
Sandra JohnenDepartment of Ophthalmology, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Sabine DiarraDepartment of Ophthalmology, University Hospital RWTH Aachen, 52074 Aachen, Germany.
Attila SebeDivision of Medical Biotechnology, Paul Ehrlich-Institut, 63225 Langen, Germany.
Juan Roberto Rodriguez-MadozRegenerative Medicine Program, Center for Applied Medical Research (CIMA), University of Navarra, IdiSNA, Pamplona 31008, Spain.
Severine PouillotGenoSafe, Evry 91000, France.
Corinne MarieUniversité de Paris, UTCBS, CNRS, INSERM, F-75006 Paris, France.
Zsuzsanna IzsvákMax Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany.
Daniel SchermanUniversité de Paris, UTCBS, CNRS, INSERM, F-75006 Paris, France.
Martina KroppExperimental Ophthalmology, University of Geneva, 1205 Geneva, Switzerland.
Felipe ProsperRegenerative Medicine Program, Center for Applied Medical Research (CIMA), University of Navarra, IdiSNA, Pamplona 31008, Spain.
Gabriele ThumannExperimental Ophthalmology, University of Geneva, 1205 Geneva, Switzerland.
Zoltán IvicsDivision of Medical Biotechnology, Paul Ehrlich-Institut, 63225 Langen, Germany.
Alfredo Garcia-LayanaExperimental Ophthalmology Laboratory, Ophthalmology, Clínica Universidad de Navarra, IdiSNA, Pamplona, Spain.
Patricia Fernandez-RobredoExperimental Ophthalmology Laboratory, Ophthalmology, Clínica Universidad de Navarra, IdiSNA, Pamplona, Spain.
Clinica Universidad de Navarra · ESPaul Ehrlich Institut · DEInstituto de Salud Carlos III · ESRWTH Aachen University · DEUniversidad de Navarra · ESUniversity Hospital of Geneva · CHBerlin Institute of Health at Charité - Universitätsmedizin Berlin · DECentre National de la Recherche Scientifique · FRGenoSafe · FRUnité de Technologies Chimiques et Biologiques pour la Santé · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related macular degeneration (AMD) is a progressive retinal disorder characterized by imbalanced pro- and antiangiogenic signals. The aim of this study was to evaluate the effect of

Indexed as

angiogenesisiris pigment epithelial cells (IPE)pigment epithelium derived factor (PEDF)retinal pigment epithelium (RPE)SB100X transposasevascular endothelial growth factor (VEGF)

Identifiers

PMID31890733
PMCPMC6909167
OpenAlexW2987505890

What Socratic holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.