ArticleCirculation2020
DP1 Activation Reverses Age-Related Hypertension Via NEDD4L-Mediated T-Bet Degradation in T Cells.
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Article in Circulation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21citing papers in PubMed
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Who cites it
21 citing papers in PubMed, 39 citations in OpenAlex.
- The ubiquitin system in heart and vessel pathobiology: From mechanisms to therapeutic strategies.Genes & diseases · 2026Review
- Endothelial AGGF1 Deficiency Causes Mitochondrial Dysfunction and Contributes to Age-Elevated Blood Pressure.Aging cell · 2026Article
- Article
- Deletion of EP3 prostaglandin receptor in murine macrophages aggravates diet-induced obesity by suppressing SPARC.The EMBO journal · 2025Article
- Elevated uric acid induces erectile dysfunction in rats by interacting with MLCK and inhibiting its ubiquitin-mediated degradation.Communications biology · 2025Article
- Further insights into influence factors of hypertension in older patients with obstructive sleep apnea syndrome: a model based on multiple centers.Aging clinical and experimental research · 2025Article
- Ubiquitination-mediated protein homeostasis in cardiovascular diseases: molecular mechanisms and therapeutic opportunities.American journal of cardiovascular disease · 2025Review
- Dual therapy with corticosteroid ablates the beneficial effect of DP2 antagonism in chronic experimental asthma.Nature communications · 2024Article
- Benefit delayed immunosenescence by regulating CD4Aging cell · 2024Review
- Ubiquitination of angiotensin-converting enzyme 2 contributes to the development of pulmonary arterial hypertension mediated by neural precursor cell-expressed developmentally down-regulated gene 4-Like.Respiratory research · 2024Article
- Prostanoids in Cardiac and Vascular Remodeling.Arteriosclerosis, thrombosis, and vascular biology · 2024Review
- Inflammation Resolution in the Cardiovascular System: Arterial Hypertension, Atherosclerosis, and Ischemic Heart Disease.Antioxidants & redox signaling · 2024Review
- NEDD4L facilitates granulosa cell ferroptosis by promoting GPX4 ubiquitination and degradation.Endocrine connections · 2023Article
- Targeting the DP2 receptor alleviates muscle atrophy and diet-induced obesity in mice through oxidative myofiber transition.Journal of cachexia, sarcopenia and muscle · 2023Article
- Smurf1 Facilitates Oxidative Stress and Fibrosis of Ligamentum Flavum by Promoting Nrf2 Ubiquitination and Degradation.Mediators of inflammation · 2023Article
- Environmental eustress improves postinfarction cardiac repair via enhancing cardiac macrophage survival.Science advances · 2022Article
- Downregulation of NEDD4L by EGFR signaling promotes the development of lung adenocarcinoma.Journal of translational medicine · 2022Article
- Identification of key differential genes in intimal hyperplasia induced by left carotid artery ligation.PeerJ · 2022Article
- ALCAP2 inhibits lung adenocarcinoma cell proliferation, migration and invasion via the ubiquitination of β-catenin by upregulating the E3 ligase NEDD4L.Cell death & disease · 2021Article
- The Effect of Lipid Metabolism on CD4Mediators of inflammation · 2021Review
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Authors and funding
15 authors at 9 institutions in 3 countries.
Deping KongDepartment of Pharmacology and Tianjin Key Laboratory of Inflammatory Biology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, China (D.K., S.Z., Q.L., Y.Y.).
Qiangyou WanCAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences (Q.W., C.W., Y.Y.), University of Chinese Academy of Sciences, Chinese Academy of Sciences, China.
Juanjuan LiDepartment of Gastroenterology (J.L.), Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China.
Shengkai ZuoDepartment of Pharmacology and Tianjin Key Laboratory of Inflammatory Biology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, China (D.K., S.Z., Q.L., Y.Y.).
Guizhu LiuNational Clinical Research Center for Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, China (G.L., Y.Y.).
Qian LiuDepartment of Pharmacology and Tianjin Key Laboratory of Inflammatory Biology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, China (D.K., S.Z., Q.L., Y.Y.).
Chenchen WangCAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences (Q.W., C.W., Y.Y.), University of Chinese Academy of Sciences, Chinese Academy of Sciences, China.
Peiyuan BaiDepartment of Cardiology (P.B., A.L.), Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China.
Sheng-Zhong DuanLaboratory of Oral Microbiology, Shanghai Research Institute of Stomatology, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, China (S.-Z.D.).
Bin ZhouState Key Laboratory of Cell Biology, Chinese Academy of Sciences Center for Excellence on Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology (B.Z.), University of Chinese Academy of Sciences, Chinese Academy of Sciences, China.
Fotini GounariDivision of Rheumatology and Knapp Center for Lupus and Immunology Research, University of Chicago, IL (F.G.).
Ankang LyuDepartment of Cardiology (P.B., A.L.), Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China.
Michael LazarusInternational Institute for Integrative Sleep Medicine (WPI-IIIS), University of Tsukuba, Tsukuba City, Ibaraki, Japan (M.L.).
Richard M BreyerDepartment of Veterans Affairs, Tennessee Valley Health Authority, and Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (R.M.B.).
Ying YuDepartment of Pharmacology and Tianjin Key Laboratory of Inflammatory Biology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), School of Basic Medical Sciences, Tianjin Medical University, China (D.K., S.Z., Q.L., Y.Y.).
Ruijin Hospital · CNShanghai Institute of Nutrition and Health · CNTianjin Medical University · CNCenter for Excellence in Molecular Cell Science · CNFirst Affiliated Hospital of Guangzhou Medical University · CNShanghai Ninth People's Hospital · CNTennessee Valley Authority · USTsukuba International University · JPUniversity of Chicago · US
Funding
TARGETED DISRUPTION OF THE 5-LIPOXYGENASE GENE IN MICEP50GM015431 · VANDERBILT UNIVERSITY · 1985 to 2005
$7.4MSignaling in the DN to DP thymocyte transitionR01AI059676 · TUFTS MEDICAL CENTER · 2004 to 2005
$732kNIAID NIH HHS R01 AI059676NIAID NIH HHS R01 AI108682NIGMS NIH HHS P50 GM015431
Abstract
backgroundBlood pressure often rises with aging, but exact mechanisms are still not completely understood. With aging, the level of proinflammatory cytokines increases in T lymphocytes. Prostaglandin D
methodsTo clarify the physiological and pathophysiological roles of DP1 in T cells with aging, peripheral blood samples were collected from young and older male participants, and CD4
resultsThe prostaglandin D
conclusionsThe prostaglandin D
Indexed as
AgingAgedAnimalsAntihypertensive AgentsCD4-Positive T-LymphocytesCyclic AMP-Dependent Protein KinasesCytokinesHumansHypertensionMiceMice, Inbred C57BLNedd4 Ubiquitin Protein LigasesProstaglandin D2Receptors, ProstaglandinSignal TransductionSp1 Transcription FactorAntihypertensive AgentsCyclic AMP-Dependent Protein KinasesCytokinesNedd4l protein, mouseNedd4 Ubiquitin Protein LigasesProstaglandin D2Receptors, ProstaglandinSp1 Transcription FactorSuperoxidesT-bet Transcription FactorT-Box Domain ProteinsagingD-prostanoid receptor 1hypertensionlymphocyteprostaglandin (PG) D2
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.