Evidence mapPaperPMID 31897474Full record

ReviewCerebral cortex (New York, N.Y. : 1991)2020

Anatomy and Physiology of Macaque Visual Cortical Areas V1, V2, and V5/MT: Bases for Biologically Realistic Models.

Simo Vanni, Henri Hokkanen, Francesca Werner, Alessandra Angelucci

Open access · bronzeAbstract readReview
In one paragraph

Review in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 66 citations in OpenAlex.

  1. Article
  2. Neuropixels reveal laminar microcircuit organization in monkey V1 in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. Neuropixels reveal structure-function relationships in monkey V1bioRxiv : the preprint server for biology · 2025
    Article
  11. Consistent Hierarchies of Single-Neuron Timescales in Mice, Macaques, and Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  12. Article
  13. Article
  14. Review
  15. Article
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  17. Review
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  19. Article
  20. Cellular and laminar architecture: A short history and commentary.The Journal of comparative neurology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 3 countries.

Simo VanniHUS Neurocenter, Department of Neurology, Helsinki University Hospital, 00290 Helsinki, Finland.
Henri HokkanenHUS Neurocenter, Department of Neurology, Helsinki University Hospital, 00290 Helsinki, Finland.
Francesca WernerHUS Neurocenter, Department of Neurology, Helsinki University Hospital, 00290 Helsinki, Finland.
Alessandra AngelucciDepartment of Ophthalmology and Visual Sciences, Moran Eye Institute, University of Utah, Salt Lake City, UT 84132, USA.
University of Helsinki · FIHelsinki University Hospital · FIUniversity of Utah · US

Funding

University of Utah Core Vision Research GrantP30EY014800 · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2005 to 2025
$1.4M
Anatomical and functional organization of inter-areal feedback circuits in the visual cortex, and their impact on neuronal responsesR01EY026812 · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · 2025 to 2025
$363k
NEI NIH HHS P30 EY014800NEI NIH HHS R01 EY019743NEI NIH HHS R01 EY026812NEI NIH HHS R01 EY031959NINDS NIH HHS U01 NS099702
6 · The paper itself

Abstract

The cerebral cortex of primates encompasses multiple anatomically and physiologically distinct areas processing visual information. Areas V1, V2, and V5/MT are conserved across mammals and are central for visual behavior. To facilitate the generation of biologically accurate computational models of primate early visual processing, here we provide an overview of over 350 published studies of these three areas in the genus Macaca, whose visual system provides the closest model for human vision. The literature reports 14 anatomical connection types from the lateral geniculate nucleus of the thalamus to V1 having distinct layers of origin or termination, and 194 connection types between V1, V2, and V5, forming multiple parallel and interacting visual processing streams. Moreover, within V1, there are reports of 286 and 120 types of intrinsic excitatory and inhibitory connections, respectively. Physiologically, tuning of neuronal responses to 11 types of visual stimulus parameters has been consistently reported. Overall, the optimal spatial frequency (SF) of constituent neurons decreases with cortical hierarchy. Moreover, V5 neurons are distinct from neurons in other areas for their higher direction selectivity, higher contrast sensitivity, higher temporal frequency tuning, and wider SF bandwidth. We also discuss currently unavailable data that could be useful for biologically accurate models.

Indexed as

AnimalsGeniculate BodiesMacacaNeuronsPrimary Visual CortexVisual CortexVisual Pathwaysbiomimeticcomputational neurosciencemicrocircuitneural networkneuroinformatics

Identifiers

PMID31897474
PMCPMC7233004
OpenAlexW2996931055

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.