Evidence map›Paper›PMID 31897490›Full record

ArticleCerebral cortex (New York, N.Y. : 1991)2020

Diminished Myoinositol in Ventromedial Prefrontal Cortex Modulates the Endophenotype of Impulsivity.

Bianca Jupp, Steve J Sawiak, Bastiaan van der Veen, Suzanne Lemstra, Chiara Toschi, Rebecca L Barlow, Anton Pekcec, Tom Bretschneider, Janet R Nicholson, Trevor W Robbins and 1 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cerebral cortex (New York, N.Y. : 1991), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 11 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 2 countries.

Bianca JuppDepartment of Psychology, University of Cambridge, Cambridge CB2 3EB, UK.
Steve J SawiakDepartment of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, UK.
Bastiaan van der VeenDepartment of Psychology, University of Cambridge, Cambridge CB2 3EB, UK.
Suzanne LemstraDepartment of Psychology, University of Cambridge, Cambridge CB2 3EB, UK.
Chiara ToschiDepartment of Psychology, University of Cambridge, Cambridge CB2 3EB, UK.
Rebecca L BarlowBoehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss 88397, Germany.
Anton PekcecBoehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss 88397, Germany.
Tom BretschneiderBoehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss 88397, Germany.
Janet R NicholsonBoehringer Ingelheim Pharma GmbH & Co. KG, Biberach an der Riss 88397, Germany.
Trevor W RobbinsDepartment of Psychology, University of Cambridge, Cambridge CB2 3EB, UK.
Jeffrey W DalleyDepartment of Psychology, University of Cambridge, Cambridge CB2 3EB, UK.
University of Cambridge · GBBoehringer Ingelheim (Germany) · DE

Funding

Medical Research Council G0001354Medical Research Council G0701500Medical Research Council G1000183Medical Research Council G1002231Medical Research Council MR/N02530X/1Wellcome TrustWellcome Trust 093875/Z/10/Z
6 · The paper itself

Abstract

Maladaptive impulsivity manifests in a variety of disorders, including attention-deficit hyperactivity disorder (ADHD), depression, and substance use disorder. However, the etiological mechanisms of impulsivity remain poorly understood. In the present study, we used in-vivo proton magnetic resonance spectroscopy (1H-MRS) to investigate neurometabolite content in the prefrontal cortex (PFC) and striatum of rats exhibiting low- versus high-impulsive (LI, HI) behavior on a visual attentional task. We validated our 1H-MRS findings using regionally resolved ex-vivo mass spectroscopy, transcriptomics, and site-directed RNA interference in the ventromedial PFC. We report a significant reduction in myoinositol levels in the PFC but not the striatum of HI rats compared with LI rats. Reduced myoinositol content was localized to the infralimbic (IL) cortex, where significant reductions in transcript levels of key proteins involved in the synthesis and recycling of myoinositol (IMPase1) were also present. Knockdown of IMPase1in the IL cortex increased impulsivity in nonimpulsive rats when the demand on inhibitory response control was increased. We conclude that diminished myoinositol levels in ventromedial PFC causally mediate a specific form of impulsivity linked to vulnerability for stimulant addiction in rodents. Myoinositol and related signaling substrates may thus offer novel opportunities for treating neuropsychiatric disorders comorbid with impulsive symptomology.

Indexed as

Impulsive BehaviorAnimalsAttentionCDP-Diacylglycerol-Inositol 3-PhosphatidyltransferaseEndophenotypesGene Knockdown TechniquesInositolIntramolecular LyasesMaleMembrane ProteinsPhosphoric Monoester HydrolasesPrefrontal CortexProton Magnetic Resonance SpectroscopyRatsSymportersCdipt protein, ratCDP-Diacylglycerol-Inositol 3-PhosphatidyltransferaseD-myo-inositol-3-phosphate synthaseInositolIntramolecular LyasesMembrane Proteinsmyo-inositol-1 (or 4)-monophosphatasePhosphoric Monoester Hydrolasessodium-myo-inositol cotransporter, ratSymportersattention-deficit hyperactivity disorderinositol monophosphatase 1 (IMPA1)inositol-triphosphate (IP3)magnetic resonance spectroscopyprefrontal cortex

Identifiers

PMID31897490
PMCPMC7197196
OpenAlexW2997300004

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.