Evidence map›Paper›PMID 31897969›Full record

ArticleJournal of molecular neuroscience : MN2020

Gypenosides Prevent H

Hong-Kan Zhang, Yuan Ye, Kai-Jun Li, Zhen-Ni Zhao, Jian-Feng He

Open access · hybridAbstract read
In one paragraph

Article in Journal of molecular neuroscience : MN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hong-Kan ZhangDepartment of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, China.
Yuan YeDepartment of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, China.
Kai-Jun LiDepartment of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, China.
Zhen-Ni ZhaoDepartment of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, China.
Jian-Feng HeDepartment of Ophthalmology, the First Affiliated Hospital of Guangxi Medical University, Nanning, 530021, Guangxi Zhuang Autonomous Region, China. hejianf@163.com.ORCID http://orcid.org/0000-0002-6792-8685
Guangxi Medical University · CN

Funding

National Natural Science Foundation of China No. 81260149Self-funded research projects of Guangxi Health and Family Planning Commission Z2016298Youth Science Foundation of Guangxi Medical University 82/02604001134X
6 · The paper itself

Abstract

Our previous study demonstrated that gypenosides (Gp) exert protective effects on retinal nerve fibers and axons in a mouse model of experimental autoimmune optic neuritis. However, the therapeutic mechanisms remain unclear. Thus, in this study, a model of oxidative damage in retinal ganglion cells (RGCs) was established to investigate the protective effect of Gp, and its possible influence on oxidative stress in RGCs. Treatment of cells with H

Indexed as

ApoptosisAnimalsAnti-Inflammatory AgentsAntioxidantsCells, CulturedCyclooxygenase 2Glutathione PeroxidaseGynostemmaHeme Oxygenase-1Hydrogen PeroxideNeuroprotective AgentsNitric Oxide Synthase Type IIOxidative StressPlant ExtractsRatsRats, Sprague-DawleyAnti-Inflammatory AgentsAntioxidantsCyclooxygenase 2Glutathione PeroxidasegypenosideHeme Oxygenase-1Hydrogen PeroxideNeuroprotective AgentsNitric Oxide Synthase Type IIPlant ExtractsGypenosidesNeuroprotectionOxidative damageRetinal ganglion ceils

Identifiers

PMID31897969
PMCPMC7066284
OpenAlexW2998640129

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.