Evidence map›Paper›PMID 31900813›Full record

Trial reportAIDS and behavior2020

"Cure" Versus "Clinical Remission": The Impact of a Medication Description on the Willingness of People Living with HIV to Take a Medication.

Ilona Fridman, Peter A Ubel, Jennifer Blumenthal-Barby, Cameron V England, Judith S Currier, Nir Eyal, Kenneth A Freedberg, Scott D Halpern, Colleen F Kelley, Daniel R Kuritzkes and 5 more

Open access · greenAbstract readRandomized Controlled Trial
In one paragraph

Trial report in AIDS and behavior, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Searching for a HIV-1 Cure.Theranostics · 2026
    Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 9 institutions in 1 country.

Ilona FridmanDuke University, 100 Fuqua Drive, Durham, NC, 27708, USA. Ilona.frdiman@duke.edu.ORCID http://orcid.org/0000-0001-6130-3134
Peter A UbelMarketing Department, Fuqua School of Business, Duke University, 100 Fuqua Drive, Durham, NC, 27708, USA.
Jennifer Blumenthal-BarbyCenter for Medical Ethics and Health Policy, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX, 77030, USA.
Cameron V EnglandEmory University School of Medicine and Grady Memorial Hospital, 201 Dowman Drive, Atlanta, GA, 30322, USA.
Judith S CurrierRonald Reagan UCLA Medical Center UCLA Medical Center, 1919 Santa Monica Blvd, Santa Monica, CA, 90404, USA.
Nir EyalDivision of Medical Ethics, Department of Global Health and Social Medicine, Harvard Medical School, Boston, MA, USA.
Kenneth A FreedbergMedical Practice Evaluation Center, Massachusetts General Hospital, Boston, MA, USA.
Scott D HalpernDepartments of Medicine, Medical Ethics and Health Policy, and Biostatistics, Epidemiology, and Informatics, University of Pennsylvania, Perelman School of Medicine, the Center for Health Incentives and Behavioral Economics at the Leonard Davis Institute of Health Economics, 3400 Civic Center Blvd, Philadelphia, PA, 19104, USA.
Colleen F KelleyDivision of Infectious Disease, Department of Medicine, Emory University, The Hope Clinic, 500 Irvin Ct Suite 200, Decatur, GA, USA.
Daniel R KuritzkesDivision of Infectious Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA.
Catherine N LeRonald Reagan UCLA Medical Center UCLA Medical Center, 1919 Santa Monica Blvd, Santa Monica, CA, 90404, USA.
Jeffrey L LennoxEmory University School of Medicine and Grady Memorial Hospital, 201 Dowman Drive, Atlanta, GA, 30322, USA.
Kathryn I PollakCancer Control and Population Sciences, Duke Cancer Institute, Durham, USA.
Brian J Zikmund-FisherDepartment of Health Behavior and Health Education, University of Michigan, 1415 Washington Heights, Ann Arbor, MI, 48109-2029, USA.
Karen A ScherrSchool of Medicine, Duke University, 2301 Erwin Rd, Durham, North Carolina, 27710, USA.
Duke University · USBrigham and Women's Hospital · USGrady Memorial Hospital · USRonald Reagan UCLA Medical Center · USBaylor College of Medicine · USEmory University · USHarvard University · USUniversity of Michigan · USUniversity of Pennsylvania · US

Funding

Virology and Molecular Biomarkers CoreP30AI050409 · NIAID · EMORY UNIVERSITY · PI Ann M Chahroudi, Colleen F Kelley · 2002 to 2026
$74.0M
Development and application of a new simulation model for COVID-19R01AI042006 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Kenneth Alan Freedberg, Anne Neilan · 1998 to 2026
$12.9M
HIV cure studies: risk, risk perception, and ethicsR01AI114617 · NIAID · RUTGERS BIOMEDICAL/HEALTH SCIENCES-RBHS · PI EYAL, NIR · 2015 to 2018
$3.2M
HIV cure studies: risk, risk perception, and ethicsR56AI114617 · NIAID · HARVARD MEDICAL SCHOOL · PI EYAL, NIR · 2014 to 2014
$528k
NIAID NIH HHS P30 AI050409NIAID NIH HHS R01 AI042006NIAID NIH HHS R01 AI114617NIAID NIH HHS R56 AI114617NIH HHS R56AI114617
6 · The paper itself

Abstract

Many people living with HIV (PLWHIV) state that they would be willing to take significant risks to be "cured" of the virus. However, how they interpret the word "cure" in this context is not clear. We used a randomized survey to examine whether PLWHIV had a different willingness to take a hypothetical HIV medication if it causes flu-like symptoms, but provides: (a) cure, (b) remission that was labeled "cure", or (c) remission. PLWHIV (n = 454) were more willing to take a medication that provided a "cure" versus a "remission" if the side effects lasted less than 1 year. PLWHIV were more willing to take a medication that provided a remission that was labeled "cure" versus a "remission" (p = 0.01) if the side effects lasted 2 weeks. Clinicians and researchers should be aware of the impact of the word "cure" and ensure that PLWHIV fully understand the possible outcomes of their treatment options.

Indexed as

Decision MakingDrug TherapyFemaleHIV InfectionsHumansIntentionMaleMiddle AgedPatientsResearch PersonnelSurveys and QuestionnairesBehaviorCureDecision-makingHIVPLWHIVRemission

Identifiers

PMID31900813
PMCPMC7319892
OpenAlexW2997931376

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.