Evidence map›Paper›PMID 31904340›Full record

ArticleeLife2020

In vivo single-cell lineage tracing in zebrafish using high-resolution infrared laser-mediated gene induction microscopy.

Sicong He, Ye Tian, Shachuan Feng, Yi Wu, Xinwei Shen, Kani Chen, Yingzhu He, Qiqi Sun, Xuesong Li, Jin Xu and 2 more

Open access · goldAbstract read
In one paragraph

Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 33 citations in OpenAlex.

  1. The endothelial scavenger receptorbioRxiv : the preprint server for biology · 2026
    Article
  2. Review
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  4. Article
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  7. iScience · 2024
    Article
  8. Review
  9. Article
  10. Article
  11. Learning from Zebrafish Hematopoiesis.Advances in experimental medicine and biology · 2023
    Review
  12. Hemogenic and aortic endothelium arise from a common hemogenic angioblast precursor and are specified by the Etv2 dosage.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  13. Article
  14. Article
  15. A single-cell resolution developmental atlas of hematopoietic stem and progenitor cell expansion in zebrafish.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  16. Review
  17. Hematopoiesis: A Layered Organization Across Chordate Species.Frontiers in cell and developmental biology · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Sicong He *Department of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Kowloon, China.ORCID 0000-0002-0399-3904
Ye Tian *State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Kowloon, China.ORCID 0000-0002-9655-7123
Shachuan Feng *State Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Kowloon, China.ORCID 0000-0001-8789-194X
Yi WuState Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Kowloon, China.
Xinwei ShenDepartment of Mathematics, The Hong Kong University of Science and Technology, Kowloon, China.
Kani ChenDepartment of Mathematics, The Hong Kong University of Science and Technology, Kowloon, China.
Yingzhu HeDepartment of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Kowloon, China.ORCID 0000-0002-2416-6254
Qiqi SunDepartment of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Kowloon, China.
Xuesong LiDepartment of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Kowloon, China.
Jin XuDivision of Cell, Developmental and Integrative Biology, School of Medicine, South China University of Technology, Guangzhou, China.ORCID 0000-0002-6840-1359
Zilong WenState Key Laboratory of Molecular Neuroscience, The Hong Kong University of Science and Technology, Kowloon, China.
Jianan Y QuDepartment of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Kowloon, China.ORCID 0000-0002-6809-0087
Hong Kong University of Science and Technology · HKSouth China University of Technology · CN

Funding

Hong Kong University of Science and Technology RPC10EG33National key R&D Program of China 2018YFA0800200Research Grants Council, University Grants Committee 16102518Research Grants Council, University Grants Committee 16103215Research Grants Council, University Grants Committee 16148816Research Grants Council, University Grants Committee 662513Research Grants Council, University Grants Committee AOE/M-09/12Research Grants Council, University Grants Committee C6002-17GFResearch Grants Council, University Grants Committee T13-605/18WResearch Grants Council, University Grants Committee T13-607/12RResearch Grants Council, University Grants Committee T13-706/11-1
6 · The paper itself

Abstract

Heterogeneity broadly exists in various cell types both during development and at homeostasis. Investigating heterogeneity is crucial for comprehensively understanding the complexity of ontogeny, dynamics, and function of specific cell types. Traditional bulk-labeling techniques are incompetent to dissect heterogeneity within cell population, while the new single-cell lineage tracing methodologies invented in the last decade can hardly achieve high-fidelity single-cell labeling and long-term in-vivo observation simultaneously. In this work, we developed a high-precision infrared laser-evoked gene operator heat-shock system, which uses laser-induced CreER

Indexed as

Cell LineageMicroscopy, ConfocalZebrafishAnimalsSingle-Cell Analysisdevelopmental biologyheat shockhematopoiesislineage tracingregenerative medicinesingle-cell labelingstem cellszebrafish

Identifiers

PMID31904340
PMCPMC7018510
OpenAlexW2996997331

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.