Evidence map›Paper›PMID 31906320›Full record

ReviewCancers2020

An Update on Neurofibromatosis Type 1-Associated Gliomas.

Mina Lobbous, Joshua D Bernstock, Elizabeth Coffee, Gregory K Friedman, Laura K Metrock, Gustavo Chagoya, Galal Elsayed, Ichiro Nakano, James R Hackney, Bruce R Korf and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.

0numbers the graph read from it
0cells of the map it votes in
53citing papers in PubMed
5.2field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

53 citing papers in PubMed, 97 citations in OpenAlex.

  1. Bridging pediatric and adult neuro-oncology: Insights into adolescents and young adults (AYA) central nervous system tumors.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Review
  2. Article
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  4. Large-Scale Assessment ofbioRxiv : the preprint server for biology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Mina LobbousDivision of Neuro Oncology, Department of Neurology, University of Alabama at Birmingham, 510 20th Street South, Faculty Office Tower suite 1020 Birmingham, Birmingham, AL 35294, USA.
Joshua D BernstockDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Elizabeth CoffeeDivision of Neuro Oncology, Department of Neurology, University of Alabama at Birmingham, 510 20th Street South, Faculty Office Tower suite 1020 Birmingham, Birmingham, AL 35294, USA.
Gregory K FriedmanDivision of Pediatric Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Laura K MetrockDivision of Pediatric Hematology and Oncology, Department of Pediatrics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Gustavo ChagoyaDepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Galal ElsayedDepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Ichiro NakanoDepartment of Neurosurgery, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
James R HackneyDepartment of Pathology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Bruce R KorfDepartment of Genetics, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Louis B NaborsDivision of Neuro Oncology, Department of Neurology, University of Alabama at Birmingham, 510 20th Street South, Faculty Office Tower suite 1020 Birmingham, Birmingham, AL 35294, USA.
University of Alabama at Birmingham · USBrigham and Women's Hospital · US

Funding

Radiation-Induced Crosstalk of Immune and Glioma Stem CellsR01NS107071 · NINDS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI NAKANO, ICHIRO · 2019 to 2019
$320k
NINDS NIH HHS R01 NS107071
6 · The paper itself

Abstract

Neurofibromatosis type 1 (NF1) is an autosomal dominant tumor predisposition syndrome that affects children and adults. Individuals with NF1 are at high risk for central nervous system neoplasms including gliomas. The purpose of this review is to discuss the spectrum of intracranial gliomas arising in individuals with NF1 with a focus on recent preclinical and clinical data. In this review, possible mechanisms of gliomagenesis are discussed, including the contribution of different signaling pathways and tumor microenvironment. Furthermore, we discuss the recent notable advances in the developing therapeutic landscape for NF1-associated gliomas including clinical trials and collaborative efforts.

Indexed as

astrocytomaglioblastomagliomasneurofibromatosistherapeutics

Identifiers

PMID31906320
PMCPMC7017116
OpenAlexW2998595859

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.