Evidence map›Paper›PMID 31907321›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2020

Specialized stellate cells offer a privileged route for rapid water flux in

Pablo Cabrero, Selim Terhzaz, Anthony J Dornan, Saurav Ghimire, Heather L Holmes, Daniel R Turin, Michael F Romero, Shireen A Davies, Julian A T Dow

Open access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.2field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 52 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. The cryptonephridial/rectal complex: an evolutionary adaptation for water and ion conservation.Biological reviews of the Cambridge Philosophical Society · 2025
    Review
  5. The Power of Drosophila in Modeling Cancer Cachexia.Advances in experimental medicine and biology · 2025
    Review
  6. Paraneoplastic renal dysfunction in fly cancer models driven by inflammatory activation of stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Transcriptional and functional motifs defining renal function revealed by single-nucleus RNA sequencing.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  18. Updates on ion and water transport by the Malpighian tubule.Current opinion in insect science · 2021
    Review
  19. Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Pablo CabreroInstitute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, G12 8QQ Glasgow, United Kingdom.ORCID 0000-0003-2141-7852
Selim TerhzazInstitute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, G12 8QQ Glasgow, United Kingdom.ORCID 0000-0002-6192-6558
Anthony J DornanInstitute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, G12 8QQ Glasgow, United Kingdom.
Saurav GhimireInstitute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, G12 8QQ Glasgow, United Kingdom.
Heather L HolmesDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine & Science, Rochester, MN 55905.
Daniel R TurinDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine & Science, Rochester, MN 55905.
Michael F RomeroDepartment of Physiology and Biomedical Engineering, Mayo Clinic College of Medicine & Science, Rochester, MN 55905.
Shireen A DaviesInstitute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, G12 8QQ Glasgow, United Kingdom.
Julian A T DowInstitute of Molecular, Cell and Systems Biology, College of Medical, Veterinary and Life Sciences, University of Glasgow, G12 8QQ Glasgow, United Kingdom; julian.dow@glasgow.ac.uk.ORCID 0000-0002-9595-5146
University of Glasgow · GBMayo Clinic · US

Funding

VISUALIZATION AND PATHOPHYSIOLOGY OF RENAL STONE PRECURSOR LESIONSU54DK100227 · NIDDK · MAYO CLINIC ROCHESTER · PI RULE, ANDREW DAVID · 2013 to 2017
$6.3M
Mayo Clinic Summer Undergraduate Research in Nephrology & UrologyR25DK101405 · NIDDK · MAYO CLINIC ROCHESTER · PI MICHAEL F. ROMERO · 2014 to 2026
$1.6M
Drosophila model of oxalate nephrolithiasisR01DK092408 · NIDDK · MAYO CLINIC ROCHESTER · PI DOW, JULIAN ALEXANDER, ROMERO, MICHAEL F. · 2012 to 2015
$837k
Biotechnology and Biological Sciences Research Council BB/L002647/1Biotechnology and Biological Sciences Research Council BB/P008097/1Medical Research Council MC_PC_17190NIDDK NIH HHS R01 DK092408NIDDK NIH HHS R25 DK101405NIDDK NIH HHS U54 DK100227
6 · The paper itself

Abstract

Insects are highly successful, in part through an excellent ability to osmoregulate. The renal (Malpighian) tubules can secrete fluid faster on a per-cell basis than any other epithelium, but the route for these remarkable water fluxes has not been established. In

Indexed as

AnimalsAquaglyceroporinsAquaporinsBiological TransportCell Membrane PermeabilityChloridesDrosophila melanogasterDrosophila ProteinsFemaleGene Knockdown TechniquesKidney TubulesMaleMalpighian TubulesModels, AnimalOocytesOsmoregulationAquaglyceroporinsAquaporinsChloridesDrosophila ProteinsWateraquaporinDrosophila melanogasterMalpighian tubulestellate cellXenopus oocyte

Identifiers

PMID31907321
PMCPMC6983416
OpenAlexW2999211684

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.